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Retzius cells retain functional membrane properties following ‘ablation’ by the neurotoxin 5,7-DHT

Lent, Charles M. and Dickinson, Michael H. (1984) Retzius cells retain functional membrane properties following ‘ablation’ by the neurotoxin 5,7-DHT. Brain Research, 300 (1). pp. 167-171. ISSN 0006-8993. https://resolver.caltech.edu/CaltechAUTHORS:20181116-073530126

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Abstract

The neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) is generally believed to selectively ablate serotonergic neurons. Serotonin-containing Retzius cells (RZ) in the leech appear ablated by 5,7-DHT treatment. However, these brown, mis-shapen, non-fluorescent neurons retain their synaptic inputs, action potentials, electronic outputs, a membrane receptor, and axonal projections.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0006-8993(84)91353-2DOIArticle
ORCID:
AuthorORCID
Dickinson, Michael H.0000-0002-8587-9936
Additional Information:© 1984 Published by Elsevier B.V. Accepted 17 January 1984. We thank C, G. Marshall for helpful comments. Supported by PHS Grant NS-14482 to C.M.L.
Funders:
Funding AgencyGrant Number
NIHNS-14482
Subject Keywords:leech; Retzius cell; serotonin; 5-hydroxytryptamine; 5,7-dihydroxytryptamine; ablation; glyoxylic acid; fluorescence
Issue or Number:1
Record Number:CaltechAUTHORS:20181116-073530126
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181116-073530126
Official Citation:Charles M. Lent, Michael H. Dickinson, Retzius cells retain functional membrane properties following ‘ablation’ by the neurotoxin 5,7-DHT, Brain Research, Volume 300, Issue 1, 1984, Pages 167-171, ISSN 0006-8993, https://doi.org/10.1016/0006-8993(84)91353-2. (http://www.sciencedirect.com/science/article/pii/0006899384913532)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90939
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Nov 2018 18:59
Last Modified:03 Oct 2019 20:30

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