Lent, Charles M. and Dickinson, Michael H. (1984) Retzius cells retain functional membrane properties following ‘ablation’ by the neurotoxin 5,7-DHT. Brain Research, 300 (1). pp. 167-171. ISSN 0006-8993. https://resolver.caltech.edu/CaltechAUTHORS:20181116-073530126
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Abstract
The neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) is generally believed to selectively ablate serotonergic neurons. Serotonin-containing Retzius cells (RZ) in the leech appear ablated by 5,7-DHT treatment. However, these brown, mis-shapen, non-fluorescent neurons retain their synaptic inputs, action potentials, electronic outputs, a membrane receptor, and axonal projections.
| Item Type: | Article | ||||||
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| Additional Information: | © 1984 Published by Elsevier B.V. Accepted 17 January 1984. We thank C, G. Marshall for helpful comments. Supported by PHS Grant NS-14482 to C.M.L. | ||||||
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| Subject Keywords: | leech; Retzius cell; serotonin; 5-hydroxytryptamine; 5,7-dihydroxytryptamine; ablation; glyoxylic acid; fluorescence | ||||||
| Issue or Number: | 1 | ||||||
| Record Number: | CaltechAUTHORS:20181116-073530126 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20181116-073530126 | ||||||
| Official Citation: | Charles M. Lent, Michael H. Dickinson, Retzius cells retain functional membrane properties following ‘ablation’ by the neurotoxin 5,7-DHT, Brain Research, Volume 300, Issue 1, 1984, Pages 167-171, ISSN 0006-8993, https://doi.org/10.1016/0006-8993(84)91353-2. (http://www.sciencedirect.com/science/article/pii/0006899384913532) | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 90939 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 16 Nov 2018 18:59 | ||||||
| Last Modified: | 03 Oct 2019 20:30 |
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