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Social structures depend on innate determinants and chemosensory processing in Drosophila

Schneider, Jonathan and Dickinson, Michael H. and Levine, Joel D. (2012) Social structures depend on innate determinants and chemosensory processing in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 109 (Suppl. 2). pp. 17174-17179. ISSN 0027-8424. PMCID PMC3477376. https://resolver.caltech.edu/CaltechAUTHORS:20181116-113011346

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Abstract

Flies display transient social interactions in groups. However, whether fly–fly interactions are stochastic or structured remains unknown. We hypothesized that groups of flies exhibit patterns of social dynamics that would manifest as nonrandom social interaction networks. To test this, we applied a machine vision system to track the position and orientation of flies in an arena and designed a classifier to detect interactions between pairs of flies. We show that the vinegar fly, Drosophila melanogaster, forms nonrandom social interaction networks, distinct from virtual network controls (constructed from the intersections of individual locomotor trajectories). In addition, the formation of interaction networks depends on chemosensory cues. Gustatory mutants form networks that cannot be distinguished from their virtual network controls. Olfactory mutants form networks that are greatly disrupted compared with control flies. Different wild-type strains form social interaction networks with quantitatively different properties, suggesting that the genes that influence this network phenotype vary across and within wild-type populations. We have established a paradigm for studying social behaviors at a group level in Drosophila and expect that a genetic dissection of this phenomenon will identify conserved molecular mechanisms of social organization in other species.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1073/pnas.1121252109DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477376/PubMed CentralArticle
http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1121252109/-/DCSupplementalPublisherSupporting Information
ORCID:
AuthorORCID
Dickinson, Michael H.0000-0002-8587-9936
Additional Information:© 2012 National Academy of Sciences. Edited by Gene E. Robinson, University of Illinois at Urbana–Champaign, Urbana, IL, and approved May 14, 2012 (received for review February 9, 2012) We thank Jean-Christoph Billeter, Jayed Atallah, Rebecca Rooke, Altaf Ramji, Carl Bergstrom, Phillip Kim, Laurent Keller, Bruce Schneider, Andrew Straw, and Kristin Branson for their suggestions and discussion. This study was funded by grants from the Canada Research Chair, the Canadian Institutes of Health Research, and the National Sciences and Engineering Research Council of Canada (to J.D.L.) and by National Science Foundation Grant 0623527 (to M.H.D.). Author contributions: J.S. and J.D.L. designed research; J.S. and J.D.L. performed research; J.S. and M.H.D. contributed new reagents/analytic tools; J.S. analyzed data; and J.S., M.H.D., and J.D.L. wrote the paper. The authors declare no conflict of interest. This article is a PNAS Direct Submission. This paper results from the Arthur M. Sackler Colloquium of the National Academy of Sciences, “Biological Embedding of Early Social Adversity: From Fruit Flies to Kindergartners,” held December 9–10, 2011, at the Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering in Irvine, CA. The complete program and audio files of most presentations are available on the NAS Web site at www.nasonline.org/biological-embedding. This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1121252109/-/DCSupplemental.
Funders:
Funding AgencyGrant Number
Canada Research Chairs ProgramUNSPECIFIED
Canadian Institutes of Health Research (CIHR)UNSPECIFIED
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
NSFEF-0623527
Subject Keywords:social network | emergent phenotypes | complex systems
Issue or Number:Suppl. 2
PubMed Central ID:PMC3477376
Record Number:CaltechAUTHORS:20181116-113011346
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181116-113011346
Official Citation:Social structures depend on innate determinants and chemosensory processing in Drosophila. Jonathan Schneider, Michael H. Dickinson, Joel D. Levine Proceedings of the National Academy of Sciences Oct 2012, 109 (Supplement 2) 17174-17179; DOI: 10.1073/pnas.1121252109
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90972
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:16 Nov 2018 21:56
Last Modified:03 Oct 2019 20:30

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