Welsch, Carole A. and Rust, William L. and Csete, Marie (2019) Concise Review: Lessons Learned from Islet Transplant Clinical Trials in Developing Stem Cell Therapies for Type 1 Diabetes. Stem Cells Translational Medicine, 8 (3). pp. 209-214. ISSN 2157-6564. PMCID PMC6392394. doi:10.1002/sctm.18-0156. https://resolver.caltech.edu/CaltechAUTHORS:20181119-083945990
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Abstract
We examined data and patterns in clinical islet transplant studies registered on clinicaltrials.gov (CTgov) for treatment of type 1 diabetes (T1D), with a goal of extracting insights to apply in the design of a pluripotent stem cell‐derived islet therapy. Clinical islet transplantation, as a cell therapy (rather than solid organ transplant) is a unique precedent for stem cell‐based islet therapies. Registration activity shows that the field is not growing significantly, and newer registrations suggest that the reasons for stagnation include need for a more optimal site of infusion/transplantation, and especially a need for better immune protective strategies to advance a more effective and durable therapy for T1D.
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| Additional Information: | © 2018 The Authors. Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. Received July 17, 2018; revised September 14, 2018; accepted for publication October 3, 2018. Author Contributions: C.A.W.: conception and design, data collection, analysis and interpretation, manuscript writing; W.L.R.: data analysis and interpretation, manuscript writing; M.C.: conception and design, data collection, analysis and interpretation, manuscript writing; C.A.W., W.L.R., and M.C.: final approval of manuscript. Disclosure of Potential Conflicts of Interest: C.A.W. discloses employment with R&D stage company. W.L.R. discloses employment and inventor/patent holder with R&D stage company. M.C. discloses Consultant/Advisory role with Seraxis, Inc. | |||||||||
| Issue or Number: | 3 | |||||||||
| PubMed Central ID: | PMC6392394 | |||||||||
| DOI: | 10.1002/sctm.18-0156 | |||||||||
| Record Number: | CaltechAUTHORS:20181119-083945990 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20181119-083945990 | |||||||||
| Official Citation: | Welsch, C. A., Rust, W. L. and Csete, M. (2019), Concise Review: Lessons Learned from Islet Transplant Clinical Trials in Developing Stem Cell Therapies for Type 1 Diabetes. Stem Cells Translational Medicine, 8: 209-214. doi:10.1002/sctm.18-0156 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 91002 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 19 Nov 2018 17:44 | |||||||||
| Last Modified: | 02 Mar 2022 00:28 |
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