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Sequence of four amino acids at the end of the single polypeptide chain of lysozyme

Schroeder, W. A. (1952) Sequence of four amino acids at the end of the single polypeptide chain of lysozyme. Journal of the American Chemical Society, 74 (1). pp. 281-282. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20181120-153101033

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Abstract

During the investigation of DNP-lysozyme in which the end group of lysozyme was found to be lysine, a DNP-peptide (or peptides) was also isolated from certain hydrolysates. The fact that this DNP-peptide material yielded α,ε-di-DNP-lysine on complete hydrolysis lead to the conclusion that it is derived from the amino end of the lysosyme molecule. Further study has now been made of this peptide material and hydrolytic conditions have been found which cause DNP-lysozyme to yield some DNP-tetrapeptide as well as shorter DNP-peptides. Analysis of the tetrapeptide and of the smaller peptides has shown that the tetrapeptide has the composiition of α,ε-di-DNP-lysyl-valyl-phenylalanyl-glycine.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/ja01121a528DOIArticle
Additional Information:© 1952 American Chemical Society. Received November 15, 1951.
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Gates and Crellin Laboratories of Chemistry1622
Issue or Number:1
Record Number:CaltechAUTHORS:20181120-153101033
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181120-153101033
Official Citation:SEQUENCE OF FOUR AMINO ACIDS AT THE AMINO END OF THE SINGLE POLYPEPTIDE CHAIN OF LYSOZYME W. A. Schroeder Journal of the American Chemical Society 1952 74 (1), 281-282 DOI: 10.1021/ja01121a528
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91109
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:21 Nov 2018 19:08
Last Modified:03 Oct 2019 20:31

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