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Cooperation Enhances Robustness of Coexistence in Spatially Structured Consortia

Ren, Xinying and Murray, Richard M. (2019) Cooperation Enhances Robustness of Coexistence in Spatially Structured Consortia. In: 2019 18th European Control Conference (ECC). IEEE , Piscataway, NJ, pp. 2651-2656. ISBN 978-3-907144-00-8.

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Designing synthetic microbial consortia is an emerging area in synthetic biology and a major goal is to realize stable and robust coexistence of multiple species. Cooperation and competition are fundamental intra/interspecies interactions that shape population level behaviors, yet it is not well-understood how these interactions affect the stability and robustness of coexistence. In this paper, we show that communities with cooperative interactions are more robust to population disturbance, e.g., depletion by antibiotics, by forming intermixed spatial patterns. Meanwhile, competition leads to population spatial heterogeneity and more fragile coexistence in communities. Using reaction-diffusion and nonlocal PDE models and simulations of a two-species E. coli consortium, we demonstrate that cooperation is more beneficial than competition in maintaining coexistence in spatially structured consortia, but not in well-mixed environments. This also suggests a tradeoff between constructing heterogeneous communities with localized functions and maintaining robust coexistence. The results provide general strategies for engineering spatially structured consortia by designing interspecies interactions and suggest the importance of cooperation for biodiversity in microbial community.

Item Type:Book Section
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Murray, Richard M.0000-0002-5785-7481
Additional Information:© 2019 EUCA. The authors would like to thank Fangzhou Xiao for his insightful discussion. The author X. R is partially supported by the Air Force Office of Scientific Research, grant number FA9550-14-1-0060. The project depicted is also sponsored by the Defense Advanced Research Projects Agency (Agreement HR0011-17-2-0008). The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.
Funding AgencyGrant Number
Air Force Office of Scientific Research (AFOSR)FA9550-14-1-0060
Defense Advanced Research Projects Agency (DARPA)HR0011-17-2-0008
Record Number:CaltechAUTHORS:20181128-093526570
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Official Citation:X. Ren and R. M. Murray, "Cooperation Enhances Robustness of Coexistence in Spatially Structured Consortia," 2019 18th European Control Conference (ECC), Naples, Italy, 2019, pp. 2651-2656. doi: 10.23919/ECC.2019.8796069
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91276
Deposited By: George Porter
Deposited On:28 Nov 2018 18:15
Last Modified:30 Mar 2020 21:27

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