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Significance of continued virus production in tissue cultures rendered neoplastic by polyoma virus

Dulbecco, Renato and Vogt, Marguerite (1960) Significance of continued virus production in tissue cultures rendered neoplastic by polyoma virus. Proceedings of the National Academy of Sciences of the United States of America, 46 (12). pp. 1617-1623. ISSN 0027-8424. PMCID PMC223093.

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The infection with polyoma (PY) virus of monolayer cultures of either mouse or hamster embryo cells gives rise to a neoplastic transformation of the cultures.(1) Previous results showed that the transformed hamster cultures did not release any virus, whereas the transformed mouse cultures continued to release PY virus indefinitely; in the latter case, the virus released was invariably a mutant of small-plaque (sp) type.(2) We have since observed that in some cases transformed hamster cultures also continue to release virus indefinitely and that the virus released is also of the sp type.

Item Type:Article
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Additional Information:© 1960 by the National Academy of Sciences. Communicated by G.W. Beadle, October 24, 1960. Aided by grants from the American Cancer Society, the U.S. PHS (grant RG 6965), and the National Foundation.
Funding AgencyGrant Number
American Cancer SocietyUNSPECIFIED
NIHRG 6965
National Foundation for Infantile ParalysisUNSPECIFIED
Issue or Number:12
PubMed Central ID:PMC223093
Record Number:CaltechAUTHORS:DULpnas60
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9137
Deposited By: Tony Diaz
Deposited On:01 Nov 2007
Last Modified:02 Oct 2019 23:57

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