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Fluorescence apertureless near-field microscope: a step toward imaging information in DNA

Quake, Stephen R. and Yang, T. J. and Lessard, Guillaume A. and Unger, Marc and Kartalov, Emil (2000) Fluorescence apertureless near-field microscope: a step toward imaging information in DNA. In: Scanning and Force Microscopies for Biomedical Applications II. Proceedings of SPIE. No.3922. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 199-204. ISBN 9780819435385. https://resolver.caltech.edu/CaltechAUTHORS:20181204-132722458

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Abstract

Single molecule imaging with optical methods has become an important tool in biophysical studies. However, when imaging molecules at room temperature using far field optics, one can only resolve molecules that are separated by a distance greater than the diffraction limit of the microscope, about 220 nanometers. Near field techniques have allowed researchers to image with resolutions on the order of 30-50 nanometers. However, there are numerous reasons to try to push the resolution limit further. One that particular concerns our group is the \notion to try to image information in DNA in order to measure sequence information. To that end, we have developed a new type of near field microscope, the fluorescence apertureless near field microscope.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.383349DOIArticle
Additional Information:© 2000 Society of Photo-Optical Instrumentation Engineers (SPIE).
Subject Keywords:Near Field Microscopy, Single Molecule Imaging, DNA Analysis
Series Name:Proceedings of SPIE
Issue or Number:3922
Record Number:CaltechAUTHORS:20181204-132722458
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181204-132722458
Official Citation:Stephen R. Quake, T. Jason Yang, Guillaume A. Lessard, Marc Unger, Emil Kartalov, "Fluorescence apertureless near-field microscope: a step toward imaging information in DNA," Proc. SPIE 3922, Scanning and Force Microscopies for Biomedical Applications II, (21 April 2000); doi: 10.1117/12.383349
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91451
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:06 Dec 2018 16:35
Last Modified:03 Oct 2019 20:35

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