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Triangular DNA Origami Tilings

Tikhomirov, Grigory and Petersen, Philip and Qian, Lulu (2018) Triangular DNA Origami Tilings. Journal of the American Chemical Society, 140 (50). pp. 17361-17364. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20181204-154459814

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Abstract

DNA origami tilings provide methods for creating complex molecular patterns and shapes using flat DNA origami structures as building blocks. Square tiles have been developed to construct micrometer-scale arrays and to generate patterns using stochastic or deterministic strategies. Here we show triangular tiles as a complementary approach for enriching the design space of DNA tilings and for extending the shape of the self-assembled arrays from 2D to 3D. We introduce a computational approach for maximizing binding specificity in a fully symmetric tile design, with which we construct a 20-tile structure resembling a rhombic triacontahedron. We demonstrate controlled transition between 3D and 2D structures using simple methods including tile concentration, magnesium, and fold symmetry in tile edge design. Using these approaches, we construct 2D arrays with unbounded and designed sizes. The programmability of the edge design and the flexibility of the structure make the triangular DNA origami tile an ideal building block for complex self-assembly and reconfiguration in artificial molecular machines and fabricated nanodevices.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/jacs.8b10609DOIArticle
https://pubs.acs.org/doi/suppl/10.1021/jacs.8b10609PublisherSupporting Information
ORCID:
AuthorORCID
Qian, Lulu0000-0003-4115-2409
Additional Information:© 2018 American Chemical Society. ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. Received: October 5, 2018; Published: December 4, 2018. The authors thank A. McDowall and A. Malyutin for the assistance with TEM imaging. G.T. and L.Q. were supported by a BWF grant (1010684) and the Shurl and Kay Curci Foundation. P.P. was supported by a NIH/NRSA training grant (5 T32 GM07616). L.Q. was also supported by an NSF award (1351081). The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
Burroughs Wellcome Fund1010684
Shurl and Kay Curci FoundationUNSPECIFIED
NIH Predoctoral Fellowship5 T32 GM07616
NSFCCF-1351081
Record Number:CaltechAUTHORS:20181204-154459814
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181204-154459814
Official Citation:Triangular DNA Origami Tilings. Grigory Tikhomirov, Philip Petersen, and Lulu Qian. Journal of the American Chemical Society 2018 140 (50), 17361-17364. DOI: 10.1021/jacs.8b10609
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91489
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:05 Dec 2018 15:33
Last Modified:20 Dec 2018 16:52

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