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Oxygen transporter for the hypoxic transplantation site

Komatsu, Hirotake and Cook, Colin A. and Gonzalez, Nelson and Medrano, Leonard and Salgado, Mayra and Sui, Feng and Liu, Junfeng and Kandeel, Fouad and Mullen, Yoko and Tai, Yu-Chong (2019) Oxygen transporter for the hypoxic transplantation site. Biofabrication, 11 (1). Art. No. 015011. ISSN 1758-5090. http://resolver.caltech.edu/CaltechAUTHORS:20181207-084047149

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Abstract

Cell transplantation is a promising treatment for complementing lost function by replacing new cells with a desired function, e.g. pancreatic islet transplantation for diabetics. To prevent cell obliteration, oxygen supply is critical after transplantation, especially until the graft is sufficiently re-vascularized. To supply oxygen during this period, we developed a chemical-/electrical-free implantable oxygen transporter that delivers oxygen to the hypoxic graft site from ambient air by diffusion potential. This device is simply structured using a biocompatible silicone-based body that holds islets, connected to a tube that opens outside the body. In computational simulations, the oxygen transporter increased the oxygen level to >120 mmHg within grafts; in contrast, a control device that did not transport oxygen showed <6.5 mmHg. In vitro experiments demonstrated similar results. To test the effectiveness of the oxygen transporter in vivo, we transplanted pancreatic islets, which are susceptible to hypoxia, subcutaneously into diabetic rats. Islets transplanted using the oxygen transporter showed improved graft viability and cellular function over the control device. These results indicate that our oxygen transporter, which is safe and easily fabricated, effectively supplies oxygen locally. Such a device would be suitable for multiple clinical applications, including cell transplantations that require changing a hypoxic microenvironment into an oxygen-rich site.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1088/1758-5090/aaf2f0DOIArticle
ORCID:
AuthorORCID
Komatsu, Hirotake0000-0003-0876-4809
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2018 IOP Publishing Ltd. Received 27 July 2018. Accepted 22 November 2018. Accepted Manuscript online 22 November 2018. Published 7 December 2018.
Funders:
Funding AgencyGrant Number
Nora Eccles Treadwell FoundationUNSPECIFIED
Caltech-City of Hope Biomedical InitiativeUNSPECIFIED
Record Number:CaltechAUTHORS:20181207-084047149
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181207-084047149
Official Citation:Hirotake Komatsu et al 2019 Biofabrication 11 015011
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91559
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:07 Dec 2018 16:59
Last Modified:07 Dec 2018 16:59

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