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Focusing light into biological tissue: how effective is it?

Wang, Lihong V. (2000) Focusing light into biological tissue: how effective is it? In: Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical. Proceedings of SPIE. No.3914. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 282-290. ISBN 9780819435309. http://resolver.caltech.edu/CaltechAUTHORS:20181207-161547916

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Abstract

Focusing light into a turbid medium was studied with Monte Carlo simulations. Focusing was found to have a significant impact on the absorption distribution in turbid media when the depth of the focal point (the distance between the focal point and the surface of the turbid media) was less than or comparable with the transport mean free path. Focusing could significantly increase the peak absorption and narrow the absorption distribution. As the depth of the focal point increased, the peak absorption decreased, and the depth of peak absorption increased initially but quickly reached a plateau that was less than the transport mean free path. A refractive-index-mismatched boundary between the ambient medium and the turbid medium deteriorated the focusing effect, increased the absorption near the boundary, lowered the peak absorption, and broadened the absorption distribution.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.388053DOIBook Section
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2000 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored in part by the National Institutes of Health grants R29 CA68562 and R01 CA71980, and the National Science Foundation grant BES-9734491.
Funders:
Funding AgencyGrant Number
NIHR29 CA68562
NIHR01 CA71980
NSFBES-9734491
Record Number:CaltechAUTHORS:20181207-161547916
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181207-161547916
Official Citation:Lihong V. Wang, "Focusing light into biological tissue: how effective is it?," Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); doi: 10.1117/12.388053
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91603
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:10 Dec 2018 23:34
Last Modified:10 Dec 2018 23:34

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