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Two-dimensional tissue imaging by use of parallel detection of ultrasound-modulated laser speckles

Yao, Gang and Wang, Lihong V. (2000) Two-dimensional tissue imaging by use of parallel detection of ultrasound-modulated laser speckles. In: Biomedical Optoacoustics. Proceedings of SPIE. No.3916. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 140-146. ISBN 9780819435323. http://resolver.caltech.edu/CaltechAUTHORS:20181207-161548072

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Abstract

Ultrasound-modulated optical tomography in biological tissue was studied. An ultrasonic beam was focused into a biological tissue sample to modulate the laser light passing through the ultrasonic beam inside the tissue. The speckle field formed by the transmitted laser light was detected by a CCD camera with the source-synchronous-illumination lock- in technique. The ultrasound-modulated laser light reflects the local optical and mechanical properties within the ultrasonic beam and can be used for tomographic imaging of the tissue. We implemented frequency-swept modulation to obtain spatial resolution along the ultrasonic axis. 2D images of biological tissue were successfully obtained with both single frequency modulation and frequency-swept modulation. 3D images could be acquired as well in principle.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.386314DOIBook Section
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2000 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored in part by the National Institutes of Health grants R29 CA68562, R01 CA71980, and R21 CA83760 and by the National Science Foundation grant BES-9734491.
Funders:
Funding AgencyGrant Number
NIHR29 CA68562
NIHR01 CA71980
NIHR21 CA83760
NSFBES-9734491
Subject Keywords:optical imaging, ultrasound modulation, biological tissue
Record Number:CaltechAUTHORS:20181207-161548072
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181207-161548072
Official Citation:Gang Yao, Lihong V. Wang, "Two-dimensional tissue imaging by use of parallel detection of ultrasound-modulated laser speckles," Proc. SPIE 3916, Biomedical Optoacoustics, (19 May 2000); doi: 10.1117/12.386314
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91605
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:10 Dec 2018 23:44
Last Modified:10 Dec 2018 23:44

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