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Multiple scattering in optical coherence tomography signal: Monte Carlo modeling and experimental study

Yao, Gang and Wang, Lihong (1999) Multiple scattering in optical coherence tomography signal: Monte Carlo modeling and experimental study. In: Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III. Proceedings of SPIE. No.3598. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 10-17. ISBN 9780819430687. https://resolver.caltech.edu/CaltechAUTHORS:20181207-161548522

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Abstract

The angle biased Monte Carlo technique is applied to simulate the OCT signal from homogeneous turbid medium. The OCT signal is divided into two categories: one is from a specific imaging target layer in the turbid medium; the other is from the other background medium. The Class II signal has wider spatial and angular distribution than the Class I signal. And it experiences more scattering events. The multiple scattered photons will decrease the contrast of the OCT image and their contributions become dominant at larger depths. The average number of scattering events increases with the probing depth for both Class I and II lights. Experimental study is conducted by measuring the depth-resolved degree of polarization (DOP) of the back- scattered signal from the turbid media. The DOP is derived form the Stokes vector measurements. The incident light is linear polarized and could be depolarize by the multiple scattering. The DOP decreases to 0.5 when Class I signal is equal to the Class II signal. Experiments in the intralipid solution with different scattering coefficient show the imaging depth is limited to 3-4 optical depths.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.347489DOIArticle
ORCID:
AuthorORCID
Wang, Lihong0000-0001-9783-4383
Additional Information:© 1999 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored in part by the National Institutes of Health grants R29 CA68562 and R01 CA71980 and by the National Science Foundation grant BES-9734491.
Funders:
Funding AgencyGrant Number
NIHR29 CA68562
NIHR01 CA71980
NSFBES-9734491
Subject Keywords:Optical coherence tomography, Monte Carlo, multiple scattering, depolarization, stokes vector
Series Name:Proceedings of SPIE
Issue or Number:3598
DOI:10.1117/12.347489
Record Number:CaltechAUTHORS:20181207-161548522
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181207-161548522
Official Citation:Gang Yao, Lihong V. Wang, "Multiple scattering in optical coherence tomography signal: Monte Carlo modeling and experimental study," Proc. SPIE 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, (30 April 1999); doi: 10.1117/12.347489
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91610
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:11 Dec 2018 15:32
Last Modified:16 Nov 2021 03:42

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