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Measurement of tissue optical properties and modeling of optimal light delivery for tumor treatment

Wang, Lihong V. and Marquez, Guillermo and Nordquist, Robert E. and Chen, Wei R. (1998) Measurement of tissue optical properties and modeling of optimal light delivery for tumor treatment. In: Laser-Tissue Interaction IX. Proceedings of SPIE. No.3254. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 332-341. ISBN 9780819426932. http://resolver.caltech.edu/CaltechAUTHORS:20181207-161548615

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Abstract

Oblique-incidence reflectometry was used to measure the optical properties of rat tumors with injected absorption- enhancement dye. The measured optical properties were used to model light delivery into the tissues for optimal therapeutic effects. The goal was to efficiently deliver the maximum amount of optical power into buried tumors being treated while avoiding potential damage to normal tissue caused by strong optical power deposition underneath the tissue surface illuminated by the laser beam. The distribution of power deposition was simulated for single beam delivery and multiple beam delivery as well. The simulated results showed that with an appropriate dye enhancement and an optimal laser delivery configuration, a high selectivity for laser treatment of tumors could be achieved.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.308181DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 1998 Society of Photo-Optical Instrumentation Engineers (SPIE). The project was sponsored in part by The Whitaker Foundation grant and the National Institutes of Health grant R29 CA68562 and R01 CA71980.
Funders:
Funding AgencyGrant Number
Whitaker FoundationUNSPECIFIED
NIHR29 CA68562
NIHR01 CA71980
Subject Keywords:Monte Carlo, light delivery, optical therapy, turbid media, biological tissues
Record Number:CaltechAUTHORS:20181207-161548615
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181207-161548615
Official Citation:Lihong V. Wang, Guillermo Marquez, Robert E. Nordquist, Wei R. Chen, "Measurement of tissue optical properties and modeling of optimal light delivery for tumor treatment," Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); doi: 10.1117/12.308181
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91611
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:11 Dec 2018 17:47
Last Modified:11 Dec 2018 17:47

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