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Theoretical studies of optimal light delivery for tumor treatment

Wang, Lihong and Chen, Wei R. and Nordquist, Robert E. (1997) Theoretical studies of optimal light delivery for tumor treatment. In: Laser-Tissue Interaction VIII. Proceedings of SPIE. No.2975. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 84-95. ISBN 9780819423863. https://resolver.caltech.edu/CaltechAUTHORS:20181207-161548965

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Abstract

Optimal laser light delivery into turbid biological tissue was studied using MOnte Carlo simulations. The goal was to efficiently deliver maximum amount of optical power into buried tumors being treated while avoiding damage to normal tissue caused by strong optical power deposition underneath the tissue surface illuminated by the laser beam. The buried tumors were considered to have much higher absorption than the surrounding normal tissue via selective uptake of absorption-enhancement dye by the tumor. The power delivering efficiency to buried tumors was investigated for various diameters of the laser beam. An optimal beam diameter was estimated to achieve the maximum produce of the power coupling efficiency and the power delivered to the buried tumor. The distribution of power deposition was simulated for single beam delivery and multiple beam delivery as well. The simulated results showed that with an appropriate dye enhancement and an optimal laser delivery configuration, a high selectivity for laser treatment of tumor could be achieved.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.275462DOIArticle
ORCID:
AuthorORCID
Wang, Lihong0000-0001-9783-4383
Additional Information:© 1997 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored in part by the National Institutes of Health grant R29 CA68562 and The Whitaker Foundation.
Funders:
Funding AgencyGrant Number
NIHR29 CA68562
Whitaker FoundationUNSPECIFIED
Subject Keywords:Monte Carlo, light delivery, optical therapy, turbid media, biological tissues
Series Name:Proceedings of SPIE
Issue or Number:2975
Record Number:CaltechAUTHORS:20181207-161548965
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181207-161548965
Official Citation:Lihong V. Wang, Wei R. Chen, Robert E. Nordquist, "Theoretical studies of optimal light delivery for tumor treatment," Proc. SPIE 2975, Laser-Tissue Interaction VIII, (16 June 1997); doi: 10.1117/12.275462
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91615
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:11 Dec 2018 18:21
Last Modified:03 Oct 2019 20:36

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