CaltechAUTHORS
  A Caltech Library Service

Laser optoacoustic imaging of turbid media: determination of optical properties by comparison with diffusion theory and Monte Carlo simulation

Oraevsky, Alexander and Esenaliev, Rinat and Tittel, Frank K. and Ostermeyer, Martin and Wang, Lihong and Jacques, Steven L. (1996) Laser optoacoustic imaging of turbid media: determination of optical properties by comparison with diffusion theory and Monte Carlo simulation. In: Laser-Tissue Interaction VII. Proceedings of SPIE. No.2681. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 277-284. ISBN 9780819420558. https://resolver.caltech.edu/CaltechAUTHORS:20181207-161549241

[img] PDF - Published Version
See Usage Policy.

621Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20181207-161549241

Abstract

Laser optoacoustic imaging based on time-resolved detection of laser-induced thermoelastic pressure waves can be potentially used in medicine as a diagnostic tool (tomography) and as means to measure tissue optical properties in vivo. Information on tissue optical properties in vivo is important for laser dosimetry and tissue characterization. Analysis of the profile and amplitude of laser-induced transient stress can provide direct information about absorbed energy distribution in irradiated volume. Pressure wave profiles exactly correspond to temperature distributions generated in tissues under irradiation conditions of temporal stress confinement. In this study we experimentally measured pressure wave profile and amplitude upon irradiation of highly scattering gel phantoms and aqueous solutions colored with potassium chromate and made turbid with polystyrene spheres. A wide-band lithium niobate acoustic transducer was used to detect laser-induced pressure waves. The experimentally measured laser-induced stress profiles and the results of a Monte Carlo simulation were in excellent agreement. Computer code was developed to calculate separately absorption and scattering coefficients from transient stress profiles. Our study has demonstrated feasibility of time-resolved detection of laser-induced acoustic transients as a method for tissue optical properties measurements in vivo.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.239584DOIArticle
ORCID:
AuthorORCID
Oraevsky, Alexander0000-0002-9212-6211
Wang, Lihong0000-0001-9783-4383
Additional Information:© 1996 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by the U.S. Department of Energy (DE-FG05-91ER617226) and the Whitaker Foundation.
Funders:
Funding AgencyGrant Number
Department of Energy (DOE)DE-FG05-91ER617226
Whitaker FoundationUNSPECIFIED
Subject Keywords:Acoustic transducer, laser-induced stress, optoacoustic imaging, tissue optical properties, light distribution
Series Name:Proceedings of SPIE
Issue or Number:2681
Record Number:CaltechAUTHORS:20181207-161549241
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181207-161549241
Official Citation:Alexander A. Oraevsky, Rinat O. Esenaliev, Frank K. Tittel, Martin R. Ostermeyer, Lihong V. Wang, Steven L. Jacques, "Laser optoacoustic imaging of turbid media: determination of optical properties by comparison with diffusion theory and Monte Carlo simulation," Proc. SPIE 2681, Laser-Tissue Interaction VII, (7 May 1996); doi: 10.1117/12.239584
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91618
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:11 Dec 2018 22:53
Last Modified:09 Mar 2020 13:19

Repository Staff Only: item control page