A Caltech Library Service

Ultrasound-modulated optical tomography for thick tissue imaging

Wang, Lihong and Zhao, Xuemei and Jacques, Steven L. (1995) Ultrasound-modulated optical tomography for thick tissue imaging. In: Photon Propagation in Tissues. Proceedings of SPIE. No.2626. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 237-248. ISBN 9780819419903.

[img] PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


Continuous-wave ultrasonic modulation of scattered laser light has been used to image objects in tissue-simulating turbid media for the first time. We hypothesize that the ultrasound wave focused into the turbid media modulates the laser light passing through the ultrasonic focal spot. The modulated laser light collected by a photomultiplier tube reflects the local mechanical and optical properties in the focal zone. Buried objects in 5-cm thick tissue phantoms are located with millimeter resolution by scanning and detecting alterations of the ultrasound-modulated optical signal. Ultrasound-modulated optical tomography separates the conflict between signal and resolution in purely optical imaging of tissue and does not rely on ballistic or quasi-ballistic photons but on the abundant diffuse photons. The imaging resolution is determined by the focused ultrasonic wave. This technique has the potential to provide a noninvasive, nonionizing, inexpensive diagnostic tool for diseases such as breast cancer.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Wang, Lihong0000-0001-9783-4383
Additional Information:© 1995 Society of Photo-Optical Instrumentation Engineers (SPIE). The project was sponsored in part by The University of Texas M.D. Anderson Cancer Center grant, The Whitaker Foundation grant, Department of Energy grant, and National Institutes of Health grant.
Funding AgencyGrant Number
University of Texas at AustinUNSPECIFIED
Whitaker FoundationUNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
Subject Keywords:Ultrasound-modulation, optical imaging, optical tomography, turbid media, scattering media, biological tissue phantoms
Series Name:Proceedings of SPIE
Issue or Number:2626
Record Number:CaltechAUTHORS:20181207-161549603
Persistent URL:
Official Citation:Lihong V. Wang, Xuemei Zhao, Steven L. Jacques, "Ultrasound-modulated optical tomography for thick tissue imaging," Proc. SPIE 2626, Photon Propagation in Tissues, (18 December 1995); doi: 10.1117/12.228670
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91622
Deposited By: George Porter
Deposited On:11 Dec 2018 23:15
Last Modified:16 Nov 2021 03:42

Repository Staff Only: item control page