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Non-invasive detection of skin cancers by measuring optical properties of tissues

Wang, Lihong and Jacques, Steven L. (1995) Non-invasive detection of skin cancers by measuring optical properties of tissues. In: Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V. Proceedings of SPIE. No.2395. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 548-558. ISBN 9780819417428.

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Skin cancer is the most frequently occurring cancer of all cancers. Each year over 500,000 new cases of skin cancer will be detected. A high percentage of skin cancers are diseases in which fatalities can be all but eliminated and morbidity reduced if detected early and treated properly. These skin lesions are distinguished generally by subjective visual inspection and their definitive diagnosis requires time-consuming expensive histopathological evaluation of excisional or incisional biopsies. In vivo experimental evidence published in the literature has shown that cancerous skin lesions have different total diffuse reflectance spectra than non- cancerous lesions or normal skin. Therefore, cancerous skin lesions may be differentiated from non-cancerous skin lesions by comparing the optical properties of the skin lesions with those of the surrounding normal skin sites, where the optical properties of the normal skin sites are used to account for different types of skin or different areas of skin. We have demonstrated that the effect of melanin concentration on the diffuse reflectance may be removed by extrapolating the reflectance at different wavelengths to an apparent pivot point. Because the concentration of melanin does not indicate malignancy, the removal of its effect is important to avoid false detection. The total diffuse reflectance depends on the albedo and anisotropy of tissues. Therefore, the total diffuse reflectance will remain the same as long as the anisotropy and the ratio between the absorption coefficient and the reduced scattering coefficient remain the same. Separating the absorption and scattering effects should enhance the detection sensitivity of skin cancers.

Item Type:Book Section
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Wang, Lihong0000-0001-9783-4383
Additional Information:© 1995 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported in part by the Whitaker Foundation, Office of Naval Research grant N00014-91-J-1354, Air Force Office of Scientific Research grant F49620-93-1-0298DEF, Department of Energy grant DE-FG05-91ER61226, and National Institutes of Health grant R29-HL45045.
Funding AgencyGrant Number
Whitaker FoundationUNSPECIFIED
Office of Naval Research (ONR)N00014-91-J-1354
Air Force Office of Scientific Research (AFOSR)F49620-93-1-0298DEF
Department of Energy (DOE)DE-FG05-91ER61226
Subject Keywords:Tissue optics, skin cancers, turbid media, scattering media, absorption coefficient, reduced scattering coefficient, optical properties, Monte Carlo simulation
Series Name:Proceedings of SPIE
Issue or Number:2395
Record Number:CaltechAUTHORS:20181207-161549768
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Official Citation:Lihong V. Wang, Steven L. Jacques, "Non-invasive detection of skin cancers by measuring optical properties of tissues," Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); doi: 10.1117/12.209142
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91624
Deposited By: George Porter
Deposited On:11 Dec 2018 23:34
Last Modified:16 Nov 2021 03:42

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