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Time-resolved reflectance measurements on layered tissues with strongly varying optical properties

Hielscher, Andreas H. and Liu, Hanli and Wang, L. and Tittel, Frank K. and Chance, Britton and Jacques, Steven L. (1995) Time-resolved reflectance measurements on layered tissues with strongly varying optical properties. In: Laser Interaction with Hard and Soft Tissue II. Proceedings of SPIE. No.2323. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 351-359. ISBN 9780819416568. https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550017

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Abstract

Most biological tissues consist of layers with different optical properties. A few examples are the skin, the esophagus, the stomach and the wall of arteries. An understanding of how the light propagates in such layered systems is a prerequisite for any light based therapy or diagnostic scheme. In this study we investigate the influence of different kinds of layers on time resolved reflectance measurements. Experiments were performed on layered gel phantoms and the results compared to Monte Carlo simulations and diffusion theory. It is shown that when a low absorbing medium is situated on top of a high absorbing medium, the absorption coefficient of the lower layer is accessible if the differences in the absorption coefficient are only small. In the case of large difference the optical properties of the upper layer dominate the signal and shield information on the lowest layer. The degree of this shielding effect depends on layer thickness as well as optical properties. In the case of an almost absorption and scattering free layer in between two normal tissues, an overall increase of the signal is visible. However, the overall shape of the curve is about preserved. The apparent scattering coefficient is slightly decreased, while the apparent absorption coefficient is unaltered.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.199216DOIArticle
ORCID:
AuthorORCID
Wang, L.0000-0001-9783-4383
Additional Information:© 1995 Society of Photo-Optical Instrumentation Engineers (SPIE). The authors would like to thank Dr. L. Wang for the help in performing the Monte Carlo Simulations. This work was supported in part by the Department of Energy and the Robert A. Welch Foundation.
Funders:
Funding AgencyGrant Number
Department of Energy (DOE)UNSPECIFIED
Robert A. Welch FoundationUNSPECIFIED
Series Name:Proceedings of SPIE
Issue or Number:2323
Record Number:CaltechAUTHORS:20181207-161550017
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550017
Official Citation:Andreas H. Hielscher, Hanli Liu, Lihong V. Wang, Frank K. Tittel, Britton Chance, Steven L. Jacques, "Time-resolved reflectance measurements on layered tissues with strongly varying optical properties," Proc. SPIE 2323, Laser Interaction with Hard and Soft Tissue II, (18 January 1995); doi: 10.1117/12.199216
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91627
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:12 Dec 2018 00:23
Last Modified:03 Oct 2019 20:36

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