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Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption

Hielscher, A. H. and Liu, H. and Wang, L. and Tittel, F. K. and Chance, B. and Jacques, S. L. (1994) Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption. In: Biochemical Diagnostic Instrumentation. Proceedings of SPIE. No.2136. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 4-14. ISBN 9780819414311. https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550375

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Abstract

The possibility of measuring the blood oxygenation in the brain with near infrared light has been studied. The goal of this study was to quantify the influence of different brain layers on brain blood oxygenation measurements. Experimental results obtained from time resolved reflectance measurements on layered tissue phantoms were compared to Monte Carlo simulations of layered models, diffusion theory, and in vivo measurements on the human head. Both the experimental results and simulations show that the absorption coefficient (mu) a, which is closely related to the blood oxygenation, of deeper layers can be accessed in the time domain. Thus fitting analytical expressions found from diffusion theory only to the late part of the time resolved reflectance allows us to determine (mu) a and subsequently the blood oxygenation of the deepest medium (e.g. brain tissue).


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.180783DOIArticle
ORCID:
AuthorORCID
Wang, L.0000-0001-9783-4383
Additional Information:© 1994 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported in part by the Department of Energy and the Robert A. Welch Foundation
Funders:
Funding AgencyGrant Number
Department of Energy (DOE)UNSPECIFIED
Robert A. Welch FoundationUNSPECIFIED
Series Name:Proceedings of SPIE
Issue or Number:2136
Record Number:CaltechAUTHORS:20181207-161550375
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550375
Official Citation:Hanli Liu, Andreas H. Hielscher, Bertrand Beauvoit, Lihong V. Wang, Steven L. Jacques, Frank K. Tittel, Britton Chance, "Determination of blood oxygenation in the brain by time-resolved reflectance spectroscopy: influence of the skin, skull, and meninges," Proc. SPIE 2136, Biochemical Diagnostic Instrumentation, (21 July 1994); doi: 10.1117/12.180783
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91630
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:12 Dec 2018 16:14
Last Modified:03 Oct 2019 20:36

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