CaltechAUTHORS
  A Caltech Library Service

Determination of blood oxygenation in the brain by time-resolved reflectance spectroscopy: influence of the skin, skull, and meninges

Liu, Hanli and Hielscher, Andreas H. and Beauvoit, Bertrand and Wang, Lihong and Jacques, Steven L. and Tittel, Frank K. and Chance, Britton (1994) Determination of blood oxygenation in the brain by time-resolved reflectance spectroscopy: influence of the skin, skull, and meninges. In: Biochemical Diagnostic Instrumentation. Proceedings of SPIE. No.2136. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 15-25. ISBN 9780819414311. https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550466

[img] PDF - Published Version
See Usage Policy.

835Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550466

Abstract

Near infrared light has been used for the determination of blood oxygenation in the brain but little attention has been paid to the fact that the states of blood oxygenation in arteries, veins, and capillaries differ substantially. In this study, Monte Carlo simulations for a heterogeneous system were conducted, and near infrared time-resolved reflectance measurements were performed on a heterogeneous tissue phantom model. The model was made of a solid polyester resin, which simulates the tissue background. A network of tubes was distributed uniformly through the resin to simulate the blood vessels. The time-resolved reflectance spectra were taken with different absorbing solutions filled in the network. Based on the simulation and experimental results, we investigated the dependence of the absorption coefficient obtained from the heterogeneous system on the absorption of the actual absorbing solution filled in the tubes. We show that light absorption by the brain should result from the combination of blood and blood-free tissue background.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.180773DOIArticle
ORCID:
AuthorORCID
Wang, Lihong0000-0001-9783-4383
Additional Information:© 1994 Society of Photo-Optical Instrumentation Engineers (SPIE).
Series Name:Proceedings of SPIE
Issue or Number:2136
Record Number:CaltechAUTHORS:20181207-161550466
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550466
Official Citation:Andreas H. Hielscher, Hanli Liu, Lihong V. Wang, Frank K. Tittel, Britton Chance, Steven L. Jacques, "Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption," Proc. SPIE 2136, Biochemical Diagnostic Instrumentation, (21 July 1994); doi: 10.1117/12.180773
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91631
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:12 Dec 2018 15:39
Last Modified:03 Oct 2019 20:36

Repository Staff Only: item control page