CaltechAUTHORS
  A Caltech Library Service

Light dosimetry in photodynamic therapy using optical fiber delivery

Jacques, Steven L. and Ostermeyer, Martin and Wang, Lihong and Hielscher, Andreas (1994) Light dosimetry in photodynamic therapy using optical fiber delivery. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III. Proceedings of SPIE. No.2133. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 140-149. ISBN 9780819414281. https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550553

[img] PDF - Published Version
See Usage Policy.

533Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550553

Abstract

This paper considers rapid calculations of light distributions in a tissue for photodynamic therapy. The delivery system considered is a single optical fiber, although other configurations are easily modeled. The influence of optical heterogeneities in the tissue is considered. The optical distributions surrounding an optical fiber within a tissue can be well approximated by a point source of light placed one 'reduced mean free path' (MFP) in front of the fiber tip. One MFP equals 1/(µ_a + µ_s(1-g)). Then the simple diffusion theory expression for 3D diffusion from a point source predicts the light distribution in the tissue. The influence of optical heterogeneities in the tissue can also be well approximated. A method is described for representing regions of increased absorption (such as a region with increased vascularity) as virtual sources of 'negative radiant power' such that linear superposition of the true primary source and the virtual sources yields the net light distribution in the heterogeneous tissue. The method is rapid, flexible, and generally accurate to within about 15% error. The method yields light distributions in optically complex issues.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.179977DOIArticle
ORCID:
AuthorORCID
Wang, Lihong0000-0001-9783-4383
Alternate Title:Light dosimetry in PDT using optical fiber delivery
Additional Information:© 1994 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported by the Dept. of Energy (DE-FG05-91ER617226) and the NIH (R29-HL45045).
Funders:
Funding AgencyGrant Number
Department of Energy (DOE)DE-FG05-91ER617226
NIHR29-HL45045
Series Name:Proceedings of SPIE
Issue or Number:2133
Record Number:CaltechAUTHORS:20181207-161550553
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550553
Official Citation:Steven L. Jacques, Martin R. Ostermeyer, Lihong V. Wang, Andreas H. Hielscher, "Light dosimetry in photodynamic therapy using optical fiber delivery," Proc. SPIE 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III, (19 July 1994); doi: 10.1117/12.179977
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91632
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:12 Dec 2018 15:44
Last Modified:03 Oct 2019 20:36

Repository Staff Only: item control page