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Detection of an object inside a phantom tissue using a spatial filter

Stephens, Dawn V. and Tittel, Frank and Wang, Lihong and Hielscher, Andreas and Jacques, Steven (1994) Detection of an object inside a phantom tissue using a spatial filter. In: Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases. Proceedings of SPIE. No.2135. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 200-208. ISBN 9780819414304. https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550642

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Abstract

We report the detection of an object inside a phantom tissue using a spatial filter and a 5-mW He-Ne Laser. The phantom tissue is composed of 8% scattering polystyrene spheres and is diluted to different concentrations in water. The solution is placed inside of a cuvette of length 5 cm and width 5 cm. The spatial filter, composed of a 4-cm plano-convex lens and a 10-micrometers pinhole, is able to extract ballistic and quasi-ballistic photons from the transmitted light. A photomultiplier tube is used for detection, and a lock-in amplifier is used to reduce the amount of noise in the signal. We are able to detect the object in a phantom tissue of 20 mean free paths [mfp] with a contrast of 99.0%. The contrast in a tissue with 30 mfp is 22.7%.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.175994DOIArticle
ORCID:
AuthorORCID
Wang, Lihong0000-0001-9783-4383
Additional Information:© 1994 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was performed as a summer internship cooperative between Rice University and UT MD Anderson Cancer Center in Houston, Texas. The author wishes to thank the Center for Theoretical Study of Physical Systems at Clark Atlanta University, the Rice Quantum Institute, and the Spend a Summer with a Scientist Program at Rice University for their financial contributions.
Funders:
Funding AgencyGrant Number
Clark Atlanta UniversityUNSPECIFIED
Rice Quantum InstituteUNSPECIFIED
Rice UniversityUNSPECIFIED
Series Name:Proceedings of SPIE
Issue or Number:2135
Record Number:CaltechAUTHORS:20181207-161550642
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181207-161550642
Official Citation:Dawn V. Stephens, Frank K. Tittel, Lihong V. Wang, Andreas H. Hielscher, Steven L. Jacques, "Detection of an object inside a phantom tissue using a spatial filter," Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); doi: 10.1117/12.175994
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91633
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:12 Dec 2018 15:45
Last Modified:03 Oct 2019 20:36

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