A Caltech Library Service

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra

Qu, Yuan and Shi, Junhui and Maslov, Konstantin and Wang, Lihong V. (2018) In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra. Journal of Biomedical Optics, 23 (12). Art. No. 121621. ISSN 1083-3668. PMCID PMC6318810.

[img] PDF - Published Version
Creative Commons Attribution.


Use this Persistent URL to link to this item:


Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. We quantify the water contents of tissue-mimicking hydrogel phantoms as an analog of cervical connective tissue. Applying this method to pregnant women in vivo, we observed an increase in the water content of the cervix throughout pregnancy. The application of this technique in maternal healthcare may advance our understanding of cervical remodeling and provide a sensitive method for predicting preterm birth.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2018 The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Paper 180516SSR received Aug. 26, 2018; accepted for publication Nov. 14, 2018; published online Dec. 5, 2018. We thank Professor James Ballard for closely reading the paper, Li Lin for technical support, and Alicia Brueggemann for help in the study. This project was supported in part by the March of Dimes Prematurity Research Center (3125-17303A) and the National Institutes of Health, Grant Nos. DP1 EB016986 (NIH Director’s Pioneer Award) and R01 CA186567 (NIH Director’s Transformative Research Award). Disclosures: K. Maslov has a financial interest in Microphotoacoustics, Inc. L. V. Wang has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which, however, did not support this work.
Funding AgencyGrant Number
March of Dimes Foundation3125-17303A
NIHDP1 EB016986
NIHR01 CA186567
Subject Keywords:photoacoustic endoscopy; spectroscopy; cervical examination; tissue hydration
Issue or Number:12
PubMed Central ID:PMC6318810
Record Number:CaltechAUTHORS:20181210-123533934
Persistent URL:
Official Citation:Yuan Qu, Peng Hu, Junhui Shi, Konstantin Maslov, Peinan Zhao, Chiye Li, Jun Ma, Alejandro Garcia-Uribe, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Emma Altieri, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald McCarthy, Sarah K. England, George A. Macones, Molly J. Stout, Methodius Tuuli, Lihong V. Wang, "In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra," J. Biomed. Opt. 23(12) 121621 (5 December 2018);
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91641
Deposited By: Tony Diaz
Deposited On:10 Dec 2018 21:46
Last Modified:22 Aug 2019 20:35

Repository Staff Only: item control page