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Transvaginal fast-scanning optical-resolution photoacoustic endoscopy

Qu, Yuan and Shi, Junhui and Maslov, Konstantin and Wang, Lihong V. (2018) Transvaginal fast-scanning optical-resolution photoacoustic endoscopy. Journal of Biomedical Optics, 23 (12). Art. No. 121617 . ISSN 1083-3668. PMCID PMC6279961.

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Photoacoustic endoscopy offers in vivo examination of the visceral tissue using endogenous contrast, but its typical B-scan rate is ∼10  Hz, restricted by the speed of the scanning unit and the laser pulse repetition rate. Here, we present a transvaginal fast-scanning optical-resolution photoacoustic endoscope with a 250-Hz B-scan rate over a 3-mm scanning range. Using this modality, we not only illustrated the morphological differences of vasculatures among the human ectocervix, uterine body, and sublingual mucosa but also showed the longitudinal and cross-sectional differences of cervical vasculatures in pregnant women. This technology is promising for screening the visceral pathological changes associated with angiogenesis.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2018 The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Paper 180497SSLR received Aug. 15, 2018; accepted for publication Nov. 5, 2018; published online Dec. 5, 2018. We thank Professor James Ballard for proofreading the paper, Alicia Brueggemann, and Emma Altieri for their help in the study. This project was supported in part by the March of Dimes Prematurity Research Center (3125-17303A) and the National Institutes of Health Grant Nos. DP1 EB016986 (NIH Director’s Pioneer Award) and R01 CA186567 (NIH Director’s Transformative Research Award). Disclosures: K. Maslov has a financial interest in Microphotoacoustics, Inc. L. V. Wang has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which, however, did not support this work.
Funding AgencyGrant Number
March of Dimes Foundation3125-17303A
NIHDP1 EB016986
NIHR01 CA186567
Subject Keywords:optical-resolution photoacoustic endoscopy; fast scanning; microelectromechanical system scanning mirror; cervical imaging
PubMed Central ID:PMC6279961
Record Number:CaltechAUTHORS:20181210-124531840
Persistent URL:
Official Citation:Yuan Qu, Chiye Li, Junhui Shi, Ruimin Chen, Song Xu, Hasan Rafsanjani, Konstantin Maslov, Hannah Krigman, Laura Garvey, Peng Hu, Peinan Zhao, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald McCarthy, Sarah K. England, George A. Macones, Qifa Zhou, K. Kirk Shung, Jun Zou, Molly J. Stout, Methodius Tuuli, Lihong V. Wang, "Transvaginal fast-scanning optical-resolution photoacoustic endoscopy," J. Biomed. Opt. 23(12) 121617 (5 December 2018);
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91642
Deposited By: Tony Diaz
Deposited On:10 Dec 2018 21:45
Last Modified:04 Apr 2019 00:00

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