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Dynamics of microRNA expression during mouse prenatal development

Murad, Rabi and Rahmanian, Sorena and Breschi, Alessandra and Zeng, Weihua and Mackiewicz, Mark and Williams, Brian and Davis, Carrie and Roberts, Brian and Meadows, Sarah and Moore, Dianne and Trout, Diane and Zaleski, Chris and Dobin, Alex and Sei, Lei-Hoon and Drenkow, Jorg and Scavelli, Alex and Gingeras, Thomas and Wold, Barbara and Myers, Richard M. and Guigó, Roderic and Mortazavi, Ali (2018) Dynamics of microRNA expression during mouse prenatal development. . (Unpublished) http://resolver.caltech.edu/CaltechAUTHORS:20181212-091659236

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Abstract

MicroRNAs (miRNAs) play a critical role as post-transcriptional regulators of gene expression. The ENCODE project profiled the expression of miRNAs in a comprehensive set of tissues during a time-course of mouse embryonic development and captured the expression dynamics of 785 miRNAs. We found distinct tissue and developmental stage specific miRNA expression clusters, with an overall pattern of increasing tissue specific expression as development proceeds. Comparative analysis of conserved miRNAs in mouse and human revealed stronger clustering of expression patterns by tissue types rather than by species. An analysis of messenger RNA gene expression clusters compared with miRNA expression clusters identifies the potential role of specific miRNA expression clusters in suppressing the development of other tissues in their host tissue during embryonic development. Our results provide the most comprehensive miRNA resource as an integrated part of the ENCODE reference dataset for mouse embryonic development.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/492918DOIDiscussion Paper
ORCID:
AuthorORCID
Wold, Barbara0000-0003-3235-8130
Mortazavi, Ali0000-0002-4259-6362
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. Posted December 10, 2018.
Record Number:CaltechAUTHORS:20181212-091659236
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181212-091659236
Official Citation:Dynamics of microRNA expression during mouse prenatal development. Rabi Murad, Sorena Rahmanian, Alessandra Breschi, Weihua Zeng, Brian A Williams, Mark Mackiewicz, Brian Roberts, Sarah Meadows, Dianne Moore, Carrie Davis, Diane Trout, Chris Zaleski, Alexander Dobin, Lei-Hoon Sei, Jorg Drenkow, Alex Scavelli, Thomas R Gingeras, Barbara Wold, Richard M. Myers, Roderic Guigo, Ali Mortazavi. bioRxiv 492918; doi: https://doi.org/10.1101/492918
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91702
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Dec 2018 17:52
Last Modified:12 Dec 2018 17:52

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