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Emerging evidence linking the gut microbiome to neurologic disorders

Griffiths, Jessica A. and Mazmanian, Sarkis K. (2018) Emerging evidence linking the gut microbiome to neurologic disorders. Genome Medicine, 10 . Art. No. 98. ISSN 1756-994X. PMCID PMC6302417. http://resolver.caltech.edu/CaltechAUTHORS:20181221-091725940

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Abstract

The gut microbiome contributes to the development and function of the immune, metabolic, and nervous systems. Furthermore, commensal bacteria modulate symptoms and pathology in mouse models of neuropsychiatric and neurodevelopmental diseases. Uncovering mechanisms that are utilized by the microbiome to mediate gut–brain connections may provide novel opportunities to target therapies to the gut in order to treat neurologic disorders.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1186/s13073-018-0609-3DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302417PubMed CentralArticle
ORCID:
AuthorORCID
Mazmanian, Sarkis K.0000-0003-2713-1513
Additional Information:© The Author(s). 2018. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. First Online: 21 December 2018. The authors would like to thank Gil Sharon, Brittany Needham, Bryan Yoo, Henry Schreiber IV, Tim Sampson, and Livia Hecke Morais for critically reading and providing input on this manuscript. Research in the Mazmanian laboratory is supported by funds from Lynda and Blaine Fetter, the Heritage Medical Research Institute, the Simons Foundation (322839), and the NIH (MH100556). Authors’ contributions: All of the authors contributed to writing this article and have approved the final version. The authors declare that they have no competing interests.
Group:Heritage Medical Research Institute
Funders:
Funding AgencyGrant Number
Heritage Medical Research InstituteUNSPECIFIED
Simons Foundation322839
NIHMH100556
PubMed Central ID:PMC6302417
Record Number:CaltechAUTHORS:20181221-091725940
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181221-091725940
Official Citation:Griffiths, J.A. & Mazmanian, S.K. Genome Med (2018) 10: 98. https://doi.org/10.1186/s13073-018-0609-3
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:91949
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:21 Dec 2018 18:20
Last Modified:07 Jan 2019 15:43

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