Griffiths, Jessica A. and Mazmanian, Sarkis K. (2018) Emerging evidence linking the gut microbiome to neurologic disorders. Genome Medicine, 10 . Art. No. 98. ISSN 1756-994X. PMCID PMC6302417. doi:10.1186/s13073-018-0609-3. https://resolver.caltech.edu/CaltechAUTHORS:20181221-091725940
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Abstract
The gut microbiome contributes to the development and function of the immune, metabolic, and nervous systems. Furthermore, commensal bacteria modulate symptoms and pathology in mouse models of neuropsychiatric and neurodevelopmental diseases. Uncovering mechanisms that are utilized by the microbiome to mediate gut–brain connections may provide novel opportunities to target therapies to the gut in order to treat neurologic disorders.
| Item Type: | Article | |||||||||
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| Additional Information: | © The Author(s). 2018. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. First Online: 21 December 2018. The authors would like to thank Gil Sharon, Brittany Needham, Bryan Yoo, Henry Schreiber IV, Tim Sampson, and Livia Hecke Morais for critically reading and providing input on this manuscript. Research in the Mazmanian laboratory is supported by funds from Lynda and Blaine Fetter, the Heritage Medical Research Institute, the Simons Foundation (322839), and the NIH (MH100556). Authors’ contributions: All of the authors contributed to writing this article and have approved the final version. The authors declare that they have no competing interests. | |||||||||
| Group: | Heritage Medical Research Institute | |||||||||
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| PubMed Central ID: | PMC6302417 | |||||||||
| DOI: | 10.1186/s13073-018-0609-3 | |||||||||
| Record Number: | CaltechAUTHORS:20181221-091725940 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20181221-091725940 | |||||||||
| Official Citation: | Griffiths, J.A. & Mazmanian, S.K. Genome Med (2018) 10: 98. https://doi.org/10.1186/s13073-018-0609-3 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 91949 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | George Porter | |||||||||
| Deposited On: | 21 Dec 2018 18:20 | |||||||||
| Last Modified: | 24 Feb 2022 18:11 |
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