CaltechAUTHORS
  A Caltech Library Service

Experimental observations and numerical modeling of lipid-shell microbubbles with calcium-adhering moieties for minimally-invasive treatment of urinary stones

Pishchalnikov, Yuri A. and Behnke-Parks, William and Maeda, Kazuki and Colonius, Tim and Mellema, Matthew and Hopcroft, Matthew and Luong, Alice and Wiener, Scott and Stoller, Marshall L. and Kenny, Thomas and Laser, Daniel J. (2018) Experimental observations and numerical modeling of lipid-shell microbubbles with calcium-adhering moieties for minimally-invasive treatment of urinary stones. Proceedings of Meetings on Acoustics, 35 (1). Art. No. 020008. ISSN 1939-800X. PMCID PMC7241592. https://resolver.caltech.edu/CaltechAUTHORS:20190123-101938742

[img] PDF - Published Version
See Usage Policy.

13Mb
[img] PDF - Accepted Version
See Usage Policy.

1905Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20190123-101938742

Abstract

A novel treatment modality incorporating calcium-adhering microbubbles has recently entered human clinical trials as a new minimally-invasive approach to treat urinary stones. In this treatment method, lipid-shell gas-core microbubbles can be introduced into the urinary tract through a catheter. Lipid moities with calcium-adherance properties incorporated into the lipid shell facilitate binding to stones. The microbubbles can be excited by an extracorporeal source of quasi-collimated ultrasound. Alternatively, the microbubbles can be excited by an intraluminal source, such as a fiber-optic laser. With either excitation technique, calcium-adhering microbubbles can significantly increase rates of erosion, pitting, and fragmentation of stones. We report here on new experiments using high-speed photography to characterize microbubble expansion and collapse. The bubble geometry observed in the experiments was used as one of the initial shapes for the numerical modeling. The modeling showed that the bubble dynamics strongly depends on bubble shape and stand-off distance. For the experimentally observed shape of microbubbles, the numerical modeling showed that the collapse of the microbubbles was associated with pressure increases of some two-to-three orders of magnitude compared to the excitation source pressures. This in-vitro study provides key insights into the use of microbubbles with calcium-adhering moieties in treatment of urinary stones.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1121/2.0000958DOIConference Proceedings
http://resolver.caltech.edu/CaltechAUTHORS:20190709-092102441Related ItemJournal Article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241592PubMed CentralJournal Article
ORCID:
AuthorORCID
Maeda, Kazuki0000-0002-5729-6194
Colonius, Tim0000-0003-0326-3909
Additional Information:© 2019 Acoustical Society of America. Published Online: 17 January 2019. We thank Dr. R. Shiraki for chemical analysis of stones’ composition. MS and TK are founding members of Applaud Medical. YP, WBP, MM, MH and DL are employees/investigators for Applaud Medical, where the experimental part of this work was done. Numerical modeling was performed in Caltech by TC and KM, who acknowledge support from the National Institutes of Health (P01-DK043881) and the Office of Naval Research (N00014-17-1-2676 and N0014-18-1-2625).
Funders:
Funding AgencyGrant Number
NIHP01-DK043881
Office of Naval Research (ONR)N00014-17-1-2676
Office of Naval Research (ONR)N0014-18-1-2625
Issue or Number:1
PubMed Central ID:PMC7241592
Record Number:CaltechAUTHORS:20190123-101938742
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190123-101938742
Official Citation:Experimental observations and numerical modeling of lipid-shell microbubbles with calcium-adhering moieties for minimally-invasive treatment of urinary stones. Yuri A. Pishchalnikov, William Behnke-Parks, Kazuki Maeda, Tim Colonius, Matthew Mellema, Matthew Hopcroft, Alice Luong, Scott Wiener, Marshall L. Stoller, Thomas Kenny, and Daniel J. Laser. Proceedings of Meetings on Acoustics 2018 35:1; doi: 10.1121/2.0000958
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92423
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Jan 2019 18:31
Last Modified:26 May 2020 16:14

Repository Staff Only: item control page