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Optimizing Bone Scaffold Porosity Distributions

Poh, Patrina S. P. and Valainis, Dvina and Bhattacharya, Kaushik and van Griensven, Martijn and Dondl, Patrick (2018) Optimizing Bone Scaffold Porosity Distributions. . (Submitted) http://resolver.caltech.edu/CaltechAUTHORS:20190123-111634389

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Abstract

We consider a simple one-dimensional time-dependent model for bone regeneration in the presence of a bio-resorbable polymer scaffold. Within the framework of the model, we optimize the effective mechanical stiffness of the polymer scaffold together with the regenerated bone matrix. The result of the optimization procedure is a scaffold porosity distribution which maximizes the stiffness of the scaffold-bone system over the regeneration time, such that the propensity for mechanical failure is reduced.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
http://arxiv.org/abs/1809.08179arXivDiscussion Paper
ORCID:
AuthorORCID
Bhattacharya, Kaushik0000-0003-2908-5469
Additional Information:PSP Poh and P Dondl contributed equally to this work.
Record Number:CaltechAUTHORS:20190123-111634389
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190123-111634389
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92428
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Jan 2019 20:04
Last Modified:23 Jan 2019 20:04

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