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Ablating the fixed lineage conjecture: Commentary on Kimble 1981

Sternberg, Paul W. (2019) Ablating the fixed lineage conjecture: Commentary on Kimble 1981. Developmental Biology, 446 (1). pp. 1-16. ISSN 0012-1606.

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In 1981 Judith Kimble published what became a classic paper in developmental biology (Kimble, 1981). The history of nematode cell lineage dating back to Boveri and zur Strassen in the 19th century indicated that nematodes had a fixed cell lineage. This invariance was confirmed in a modern study by Sulston and Horvitz (1977). Kimble's PhD work confirmed this except for two cases of indeterminate development (Kimble and Hirsh, 1979). As a postdoc, Kimble followed up using a laser microbeam system developed by John White (Sulston and White, 1980a, Sulston and White, 1980b) to selectively remove cells. With this system, if you can see the cell with Nomarski DIC optics, you can kill it. This paper laid the groundwork for analysis of the AC-VU decision, hence for the genetic analysis of LIN-12/Notch signaling (Greenwald, 2012), and for vulval induction, hence for the genetic analysis of the EGFR-RAS pathway (Sternberg, 2006).

Item Type:Article
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URLURL TypeDescription 1981 Article
Sternberg, Paul W.0000-0002-7699-0173
Alternate Title:Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans
Additional Information:© 2018 Published by Elsevier Inc. Under an Elsevier user license. Available online 24 January 2019.
Issue or Number:1
Record Number:CaltechAUTHORS:20190124-104128076
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Official Citation:Paul W. Sternberg, Ablating the fixed lineage conjecture: Commentary on Kimble 1981, Developmental Biology, Volume 446, Issue 1, 2019, Pages 1-16, ISSN 0012-1606, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92449
Deposited By: Tony Diaz
Deposited On:24 Jan 2019 20:13
Last Modified:10 Apr 2020 19:12

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