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Electrospun nanofiber-based niflumic acid capsules with superior physicochemical properties

Radacsi, Norbert and Giapis, Konstantinos P. and Ovari, George and Szabó-Révész, Piroska and Ambrus, Rita (2019) Electrospun nanofiber-based niflumic acid capsules with superior physicochemical properties. Journal of Pharmaceutical and Biomedical Analysis, 166 . pp. 371-378. ISSN 0731-7085. https://resolver.caltech.edu/CaltechAUTHORS:20190125-112844156

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Abstract

The aim of this study was to assess whether nanofibrous drug mats have potential as delivery systems for poorly water-soluble drugs. Amorphous nanofiber mats from a model poorly water-soluble active pharmaceutical ingredient (API), niflumic acid, together with the polymer excipient, polyvinyl pyrrolidine, were prepared by nozzle-free electrospinning. This technique offers a scalable way for drug formulation, and by increasing the surface area of the drug, the dissolution rate and therefore bioavailability of the API can be improved. In this study, both the amount of the dissolved active ingredient and the dissolution kinetics has been improved significantly when the nanofibrous mats were used in the drug formulation. A 15-fold increase in the dissolved amount of the produced amorphous niflumic acid nanofiber was observed compared to the dissolved amount of the raw drug within the first 15 minutes. Capsule formulation was made by mixing the electrospun nanofibers with a microcrystalline cellulose filler agent. When comparing the dissolution rate of the capsule formulation on the market with the nanofibrous capsules, a 14-fold increase was observed in the dissolved drug amount within the first 15 minutes.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.jpba.2019.01.037DOIArticle
ORCID:
AuthorORCID
Radacsi, Norbert0000-0002-7358-951X
Giapis, Konstantinos P.0000-0002-7393-298X
Additional Information:© 2019 Elsevier B.V. Received 9 December 2018, Revised 20 January 2019, Accepted 23 January 2019, Available online 23 January 2019.
Funders:
Funding AgencyGrant Number
Emberi Eroforrások Minisztériuma20391-3/2018/FEKUSTRAT
Subject Keywords:electrospinning; amorphous solid dispersion; poorly water-soluble drug; niflumic acid; physicochemical analysis
Record Number:CaltechAUTHORS:20190125-112844156
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190125-112844156
Official Citation:Norbert Radacsi, Konstantinos P. Giapis, George Ovari, Piroska Szabó-Révész, Rita Ambrus, Electrospun nanofiber-based niflumic acid capsules with superior physicochemical properties, Journal of Pharmaceutical and Biomedical Analysis, Volume 166, 2019, Pages 371-378, ISSN 0731-7085, https://doi.org/10.1016/j.jpba.2019.01.037. (http://www.sciencedirect.com/science/article/pii/S0731708518327511)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92472
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Jan 2019 20:05
Last Modified:03 Oct 2019 20:44

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