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Molecular genetics of anti-carbohydrate antibodies

Perlmutter, R. M. and Crews, S. T. and Klotz, J. and Livant, D. and Siu, J. and Hood, L. (1984) Molecular genetics of anti-carbohydrate antibodies. Annales de l'Institut Pasteur / Immunologie, 135 (1, Pt. 3). pp. 83-88. ISSN 0769-2625. https://resolver.caltech.edu/CaltechAUTHORS:20190130-115239915

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Abstract

Antibodies directed against carbohydrate determinants provide useful model systems for understanding the structure and organisation of antibody genes and the generation of antibody diversity. We have used three such systems, PC, DEX and GAC, and have studied the heavy chains and VH gene segments of each. In two of these systems, PC and GAC, much of the diversity in heavy-chain protein sequences results from somatic mutation events superimposed on expression of a single VH gene. In the DEX system, it appears that germ-line sequence diversity may be an important contributor to the variability in heavy-chain sequence. Detailed structural analyses of this type will ultimately provide a complete picture of the mechanisms which underlie effective humoral immunity.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/s0769-2625(84)80016-1DOIArticle
ORCID:
AuthorORCID
Hood, L.0000-0001-7158-3678
Additional Information:© 1984 Published by Elsevier Masson SAS. Supported by NIH grant AI18088. Supported by NIH predoctoral grant GM07616. Supported by NIH grant AI16913.
Funders:
Funding AgencyGrant Number
NIHAI18088
NIH Predoctoral FellowshipGM07616
NIHAI16913
Subject Keywords:mmunogenetics; Humoral immunity; Antibody diversity; Carbohydrate; Models; Immunogénétique; Immunité humorale; Diversité des anticorps; Glucide; Modèles
Issue or Number:1, Pt. 3
Record Number:CaltechAUTHORS:20190130-115239915
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190130-115239915
Official Citation:R.M. Perlmutter, S.T. Crews, J. Klotz, D. Livant, J. Siu, L. Hood, Molecular genetics of anti-carbohydrate antibodies, Annales de l'Institut Pasteur / Immunologie, Volume 135, Issue 1, Part 3, 1984, Pages 83-88, ISSN 0769-2625, https://doi.org/10.1016/S0769-2625(84)80016-1. (http://www.sciencedirect.com/science/article/pii/S0769262584800161)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92516
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:30 Jan 2019 23:56
Last Modified:03 Oct 2019 20:45

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