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Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging

Cochran, Jeffrey M. and Busch, David R. and Lin, Li and Minkoff, David L. and Schweiger, Martin and Arridge, Simon and Yodh, Arjun G. (2019) Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging. Journal of Biomedical Optics, 24 (5). Art. No., 051409. ISSN 1083-3668. PMCID PMC6345326.

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Diffuse optical tomography has demonstrated significant potential for clinical utility in the diagnosis and prognosis of breast cancer, and its use in combination with other structural imaging modalities improves lesion localization and the quantification of functional tissue properties. Here, we introduce a hybrid diffuse optical imaging system that operates concurrently with magnetic resonance imaging (MRI) in the imaging suite, utilizing commercially available MR surface coils. The instrument acquires both continuous-wave and time-domain diffuse optical data in the parallel-plate geometry, permitting both absolute assignment of tissue optical properties and three-dimensional tomography; moreover, the instrument is designed to incorporate diffuse correlation spectroscopic measurements for probing tissue blood flow. The instrument is described in detail here. Image reconstructions of a tissue phantom are presented as an initial indicator of the system’s ability to accurately reconstruct optical properties and the concrete benefits of the spatial constraints provided by concurrent MRI. Last, we briefly discuss how various data combinations that the instrument could facilitate, including tissue perfusion, can enable more comprehensive assessment of lesion physiology.

Item Type:Article
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Lin, Li0000-0002-0517-8436
Additional Information:© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Received: 19 September 2018; Accepted: 10 December 2018; Published: 24 January 2019. Funding for this work was provided by National Institutes of Health under Grant Nos. R01-EB002109, P41-RR002305, P41-EB014893, NTROI 1U54CA105480, NHLBI HL007915, the Thrasher Research Fund, and the Whitaker and Fulbright programs at the Institute for International Education. The authors would like to thank Dr. Thomas Connick for his assistance in designing and testing the system in the MRI environment, Norman Butler for his generous advice for developing a clinically deployable system, Michael Carman for his assistance in mechanical design, and the MR imaging technicians who accommodated our work amidst their busy clinical schedule. We also thank Dr. Soren D. Konecky and Dr. Regine Choe for their assistance in developing patient interfaces and instrument designs, as well as our research coordinators: Madeline Winters, Ellen Foster, Alexandra Vandegrift, Sarah Grundy, and Michelle Wong. This project builds on initial work done by Dr. Xavier Intes and Dr. Vasilis Ntziachristos; the authors appreciate their guidance. Finally, we thank Dr. Britton Chance for his vision and foundational work in the application of diffuse optics to breast cancer.
Funding AgencyGrant Number
Thrasher Research FundUNSPECIFIED
Whitaker FoundationUNSPECIFIED
Fulbright FoundationUNSPECIFIED
Issue or Number:5
PubMed Central ID:PMC6345326
Record Number:CaltechAUTHORS:20190130-121937548
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Official Citation:Jeffrey M. Cochran, David R. Busch, Li Lin, David L. Minkoff, Martin Schweiger, Simon Arridge, Arjun G. Yodh, "Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging," J. Biomed. Opt. 24(5) 051409 (24 January 2019).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92531
Deposited By: George Porter
Deposited On:31 Jan 2019 01:02
Last Modified:29 Oct 2020 21:39

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