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Architecture and Trade-offs in the Heat Shock Response System

Olsman, Noah and Amo Alonso, Carmen and Doyle, John C. (2018) Architecture and Trade-offs in the Heat Shock Response System. In: 2018 IEEE Conference on Decision and Control (CDC). IEEE , Piscataway, NJ, pp. 1096-1103. ISBN 9781538613955. http://resolver.caltech.edu/CaltechAUTHORS:20190201-143228822

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Abstract

Biological control systems often contain a wide variety of feedforward and feedback mechanisms that regulate a given process. While it is generally assumed that this apparent redundancy has evolved for a reason, it is often unclear how exactly the cell benefits from more complex circuit architectures. Here we study this problem in the context of a minimal model of the Heat Shock Response system in E. coli and show, through a combination of theory and simulation, that the complexity of the natural system outperforms hypothetical simpler architectures in a variety of robustness and efficiency tradeoffs. We have developed a significantly simplified model of the system that faithfully captures these rich issues. Because a great deal of biological detail is known about this particular system, we are able to compare simple models with more complete ones and obtain a level of theoretical and quantitative insight not generally feasible in the study of biological circuits. We primarily hope this will inform future analysis of both heat shock and newly studied biological complexity.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/cdc.2018.8619129DOIArticle
ORCID:
AuthorORCID
Olsman, Noah0000-0002-4351-3880
Doyle, John C.0000-0002-1828-2486
Additional Information:© 2018 IEEE. We thank Nikolai Matni and Fangzhou Xiao for their helpful feedback and discussion while writing this paper. The project or effort depicted was or is sponsored by the Defense Advanced Research Projects Agency (Agreement HR0011-17-2-0008) and AFOSR. The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.
Funders:
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)HR0011-17-2-0008
Air Force Office of Scientific Research (AFOSR)UNSPECIFIED
Record Number:CaltechAUTHORS:20190201-143228822
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190201-143228822
Official Citation:N. Olsman, C. A. Alonso and J. C. Doyle, "Architecture and Trade-offs in the Heat Shock Response System," 2018 IEEE Conference on Decision and Control (CDC), FL, USA, 2018, pp. 1096-1103. doi: 10.1109/CDC.2018.8619129
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92580
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:01 Feb 2019 23:42
Last Modified:01 Feb 2019 23:42

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