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5'-terminal structure of poliovirus polyribosomal RNA is pUp

Hewlett, Martinez J. and Rose, John K. and Baltimore, David (1976) 5'-terminal structure of poliovirus polyribosomal RNA is pUp. Proceedings of the National Academy of Sciences of the United States of America, 73 (2). pp. 327-330. ISSN 0027-8424. doi:10.1073/pnas.73.2.327.

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Poliovirus RNA purified from virus-specific polyribosomes does not contain m7G in a 5'-5'-pyrophosphate linkage at its 5'-end. The only potential 5'-end found in ribonuclease digests of this RNA is pUp, which is present in a yield of 1 mole/mole of poliovirus RNA. We conclude that a 5'-terminal m7G is not required for translation of at least one RNA species in animal cells.

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Baltimore, David0000-0001-8723-8190
Additional Information:© 1976 by the National Academy of Sciences. Contributed by David Baltimore, November 10, 1975. This work was supported by Grants #AI08388, CA 12174, and CA 14051 from the National Institutes of Health. M.J.H. is a Postdoctoral Fellow of the American Cancer Society. J.K.R. is a Postdoctoral Fellow of the National Cystic Fibrosis Research Foundation. D.B. is a Research Professor of the American Cancer Society.
Subject Keywords:DEAE-paper ionophoresis; mRNA; 7-methylguanosine in 5'-5'-pyrophosphate linkage
Issue or Number:2
Record Number:CaltechAUTHORS:HEWpnas76
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9274
Deposited By: Tony Diaz
Deposited On:05 Dec 2007
Last Modified:08 Nov 2021 20:57

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