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Fabry-Pérot optical sensor and portable detector for monitoring high-resolution ocular hemodynamics

Lee, Jeong Oen and Narasimhan, Vinayak and Balakrishna, Ashwin and Smith, Marcus R. and Du, Juan and Sretavan, David and Choo, Hyuck (2019) Fabry-Pérot optical sensor and portable detector for monitoring high-resolution ocular hemodynamics. IEEE Photonics Technology Letters, 31 (6). pp. 423-426. ISSN 1041-1135. PMCID PMC6879107. doi:10.1109/lpt.2019.2896840.

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Our understanding of ocular hemodynamics and its role in ophthalmic disease progression remains unclear due to the shortcomings of precise and on-demand biomedical sensing technologies. Here, we report high-resolution in vivo assessment of ocular hemodynamics using a Fabry–Pérot cavity-based micro-optical sensor and a portable optical detector. The designed optical system is capable of measuring both static intraocular pressure and dynamic ocular pulsation profiles in parallel. Through a dynamic intensity variation analysis method that improves sensing resolution by 3–4 folds, our system is able to extract systolic/diastolic phases from a single ocular pulsation profile. Using a portable detector, we performed in vivo studies on rabbits and verified that the ophthalmic parameters obtained from our optical system closely match with traditional techniques such as tonometry, electrocardiography, and photo-plethysmography.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Lee, Jeong Oen0000-0001-5060-8370
Narasimhan, Vinayak0000-0003-4165-402X
Du, Juan0000-0001-7428-0576
Choo, Hyuck0000-0002-8903-7939
Additional Information:© 2019 IEEE. Manuscript received November 11, 2018; revised January 9, 2019; accepted January 19, 2019. Date of publication February 1, 2019; date of current version March 12, 2019. This work was supported in part by the National Institutes of Health under Grant EY024582, in part by the Heritage Medical Research Institute, in part by the National Research Foundation of Korea (NRF-2013R1A6A3A03026384), and in part by the Powell Foundation Award.
Group:Heritage Medical Research Institute
Funding AgencyGrant Number
Heritage Medical Research InstituteUNSPECIFIED
National Research Foundation of KoreaNRF-2013R1A6A3A03026384
Charles Lee Powell FoundationUNSPECIFIED
Subject Keywords:optical sensing, portable detector, Fabry-Pérot interferometer, implantable sensor, intraocular pressure sensor, ocular hemodynamics
Issue or Number:6
PubMed Central ID:PMC6879107
Record Number:CaltechAUTHORS:20190207-161026404
Persistent URL:
Official Citation:J. O. Lee et al., "Fabry–Pérot Optical Sensor and Portable Detector for Monitoring High-Resolution Ocular Hemodynamics," in IEEE Photonics Technology Letters, vol. 31, no. 6, pp. 423-426, 15 March15, 2019. doi: 10.1109/LPT.2019.2896840
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92775
Deposited By: Tony Diaz
Deposited On:08 Feb 2019 00:20
Last Modified:15 Feb 2022 23:53

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