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All-Armchair Graphene Nanoribbon Field Effect Uridine Diphosphate Glucose Sensor: First-Principles In-Silico Design and Characterization

Jaramillo-Botero, Andres and Marmolejo-Tejada, Juan M. (2019) All-Armchair Graphene Nanoribbon Field Effect Uridine Diphosphate Glucose Sensor: First-Principles In-Silico Design and Characterization. IEEE Sensors Journal, 19 (11). pp. 3975-3983. ISSN 1530-437X. https://resolver.caltech.edu/CaltechAUTHORS:20190207-161824714

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Abstract

Label-free sensors capable of detecting low concentrations of significant biomolecular substances without inducing immune response would simplify experiments, minimize errors, improve real-time observations, and reduce costs in probing living organisms. This paper presents a first-principles, in-silico derived, all-armchair graphene nanoribbon field-effect transistor (g-FET) device for the detection and measurement of low-concentration (pM-nM) uridine diphosphate glucose, UDP-glucose. UDP-glucose is an intermediate reactant in the synthesis of sucrose in a plant cell’s cytoplasm and an extracellular signaling molecule capable of activating downstream defense mechanisms. The unique g-FET configuration for the semiconducting channel and electrodes favors the fabrication of high-density nanoarray sensors. Optimal device electronic transport and switching properties are predicted by screening configurations with different widths, to control bandgap, and lengths, to control thermionic versus tunneling transport across the semiconducting junction. A self-assembled monolayer (SAM) of pyrene derivatives, 1-pyrenebutyric acid, is used to noncovalently functionalize the graphene surface on one end and to covalently ligate the target analyte on the other while providing mechanical, chemical, and electronic signal sensing stability. We find that the device offers a predicted limit of detection (LOD) of 0.997 n mM/L (where n is the number of sensor units in an array), with high transconductance sensitivity, 0.75– 1.5μS for 1–3 UDP-glucose molecules, at low input (V_G=0.9 V) and output voltages V_(DS)=0.1 V. Thus, a 1000×1000 nanoarray sensor would yield an LOD = 0.997 nM/L. This low-power, all-armchair g-FET sensor with SAM ligands that may be chosen to bind different biomarkers provides a unique opportunity for high throughput, real-time, low-cost, high-mobility, and minimal-calibration sensing applications.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/JSEN.2019.2896448DOIArticle
ORCID:
AuthorORCID
Jaramillo-Botero, Andres0000-0003-2844-0756
Marmolejo-Tejada, Juan M.0000-0002-2363-5100
Additional Information:© 2018 IEEE. Manuscript received December 28, 2018; accepted January 24, 2019. Date of publication January 31, 2019; date of current version May 6, 2019. This work was supported in part by International Center for Tropical Agriculture (CIAT) and in part by Colciencias, ICETEX, and the Colombian Ministry of Education within the Scientific Colombia program ÓMICAS (792-61187).
Funders:
Funding AgencyGrant Number
International Center for Tropical Agriculture (CIAT)UNSPECIFIED
Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)UNSPECIFIED
Instituto Colombiano de Crédito Educativo y Estudios Técnicos en el Exterior (ICETEX)UNSPECIFIED
Ministerio de Educación Nacional (Colombia)792-61187
Subject Keywords:Field-effect graphene nanoribbon transistor, Label-free biomarker sensor, Pyrenebutyric acid, Sucrose nano-sensor, UDP-glucose nano-sensor
Issue or Number:11
Record Number:CaltechAUTHORS:20190207-161824714
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190207-161824714
Official Citation:A. Jaramillo-Botero and J. M. Marmolejo-Tejada, "All-Armchair Graphene Nanoribbon Field-Effect Uridine Diphosphate Glucose Sensor: First-Principles In-Silico Design and Characterization," in IEEE Sensors Journal, vol. 19, no. 11, pp. 3975-3983, 1 June1, 2019. doi: 10.1109/JSEN.2019.2896448
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92776
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Feb 2019 00:29
Last Modified:09 Mar 2020 13:19

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