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All-Armchair Graphene Nanoribbon Field Effect Uridine Diphosphate Glucose Sensor: First-Principles In-Silico Design and Characterization

Jaramillo-Botero, Andres and Marmolejo-Tejada, Juan M. (2019) All-Armchair Graphene Nanoribbon Field Effect Uridine Diphosphate Glucose Sensor: First-Principles In-Silico Design and Characterization. IEEE Sensors Journal . ISSN 1530-437X. (In Press)

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Label-free sensors capable of detecting low concentrations of significant biomolecular substances without inducing immune response, would simplify experiments, minimize errors, improve real-time observations, and reduce costs in probing living organisms. This paper presents a first-principles, in-silico derived, all-armchair graphene nanoribbon (ac-GNR) field–effect transistor (g-FET) device, for the detection and measurement of low-concentration (pM-nM) uridine diphosphate glucose, UDP-glucose. UDP-glucose, is an intermediate reactant in the synthesis of sucrose in a plant cell’s cytoplasm and an extracellular signaling molecule capable of activating downstream defense mechanisms. The unique g- FET configuration for the semiconducting channel and electrodes favors fabrication of high-density nanoarray sensors. Optimal device electronic transport and switching properties are predicted by screening configurations with different widths, to control bandgap, and lengths, to control thermionic vs. tunneling transport across the semiconducting junction. A self-assembled monolayer (SAM) of pyrene derivatives, 1-pyrenebutyric acid (PyBA), is used to noncovalently functionalize the graphene surface on one end, and to covalently ligate the target analyte on the other, whilst providing mechanical, chemical and electronic signal sensing stability. We find the device offers a predicted limit of detection (LOD) of 0.997/n mM/L (where n=number of sensor units in an array), with high transconductance sensitivity, 0.75-1.5 μS for 1-3 UDPglucose molecules, at low input (VG=0.9V) and output voltages VDS = 0.1V. Thus, a 1000×1000 nanoarray sensor would yield a LOD=0.997 nM/L. This low-power, all-armchair g-FET sensor with SAM ligands that may be chosen to bind different biomarkers, provides a unique opportunity for high throughput, real-time, low-cost, high-mobility, and minimal-calibration sensing applications.

Item Type:Article
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URLURL TypeDescription
Jaramillo-Botero, Andres0000-0003-2844-0756
Additional Information:© 2018 IEEE. The authors would like to thank Joseph Tohme and Camila Rebolledo from the International Center for Tropical Agriculture (CIAT) and Bill Goddard (Caltech) for relevant discussions, and Adri C. van Duin from Penn State, for providing the ReaxFF force field file used in this work. Authors acknowledge partial support from CIAT and from Colciencias, ICETEX and the Colombian Ministry of Education, within the Scientific Colombia program OMICAS, anchored at the Pontificia Universidad Javeriana.
Funding AgencyGrant Number
Pontificia Universidad JaverianaUNSPECIFIED
Ministerio de Educación Nacional (Colombia)UNSPECIFIED
Subject Keywords:Field-effect graphene nanoribbon transistor, Label-free biomarker sensor, Pyrenebutyric acid, Sucrose nano-sensor, UDP-glucose nano-sensor
Record Number:CaltechAUTHORS:20190207-161824714
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Official Citation:A. Jaramillo-Botero and J. M. Marmolejo-Tejada, "All-Armchair Graphene Nanoribbon Field Effect Uridine Diphosphate Glucose Sensor: First-Principles In-Silico Design and Characterization," in IEEE Sensors Journal. doi: 10.1109/JSEN.2019.2896448
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92776
Deposited By: Tony Diaz
Deposited On:08 Feb 2019 00:29
Last Modified:08 Feb 2019 00:29

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