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Hot topics in epigenetic regulation of cancer self-renewal for pancreatic tumors: future trends

Andrade De Mello, Ramon and Faleiro, Inês and Apolónio, Joana D. and Tabori, Uri and Price, Aryeh J. and Roberto, Vânia P. and Castelo-Branco, Pedro (2019) Hot topics in epigenetic regulation of cancer self-renewal for pancreatic tumors: future trends. Future Oncology, 15 (7). pp. 683-685. ISSN 1479-6694. https://resolver.caltech.edu/CaltechAUTHORS:20190211-095335899

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Abstract

Self-renewal is critical in order for a cancer to proliferate, grow and eventually metastasize. Today, several molecular mechanisms are being studied, which may explain the emergence of this property in advanced cancer. Pancreatic cancer is both a deadly and highly recurrent tumor, relying heavily on accelerated proliferation. Understanding self-renewal is this tumor type is therefore likely to prove essential for reaching better disease control. Recent advances in our understanding of telomere maintenance pathways are beginning to yield those insights. Indeed, it is now known that telomerase reactivation in cancer is intimately related with expression of TERT gene. The multimodal regulation of this locus, along with transcriptional output itself, both serve as prognostic factors across a variety of tumor types.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.2217/fon-2018-0153DOIArticle
Additional Information:© 2019 Future Medicine Ltd. First draft submitted: 24 February 2018; Accepted for publication: 19 December 2018; Published online: 29 January 2019. Financial & competing interests disclosure: RA De Mello is on advisory board/speaker for MSD, Pfizer, Zodiac, Astrazeneca and Novartis. The study received research grant N◦ 402621/2016-6 from (National Research Council) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ) Brazil, Roche and Merck Group. The study has received travel grant from Roche, BMS, Pierre Fabre and Amgen. JD Apolónio and VP Roberto were the recipients of PD/BD/105899/2014 FCT and LPCC-Fundação PT2016 fellowships, respectively. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Funders:
Funding AgencyGrant Number
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ)402621/2016-6
Roche and Merck GroupUNSPECIFIED
RocheUNSPECIFIED
BMSUNSPECIFIED
Pierre FabreUNSPECIFIED
AmgenUNSPECIFIED
Fundação para a Ciência e a Tecnologia (FCT)PD/BD/105899/2014
Fundação para a Ciência e a Tecnologia (FCT)LPCC-Fundação PT2016
Subject Keywords:biomarkers; gastrointestinal; molecular oncology; oncogenes; pancreatic-biliary; THOR
Issue or Number:7
Record Number:CaltechAUTHORS:20190211-095335899
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190211-095335899
Official Citation:Hot topics in epigenetic regulation of cancer self-renewal for pancreatic tumors: future trends. Ramon Andrade De Mello, Inês Faleiro, Joana D Apolónio, Uri Tabori, Aryeh J Price, Vânia P Roberto, and Pedro Castelo-Branco. Future Oncology 683-685, 15:7. doi: 10.2217/fon-2018-0153
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92828
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Feb 2019 22:18
Last Modified:03 Oct 2019 20:48

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