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Metallo-intercalators and metallo-insertors

Zeglis, Brian M. and Pierre, Valerie C. and Barton, Jacqueline K. (2007) Metallo-intercalators and metallo-insertors. Chemical Communications, 2007 (44). pp. 4565-4579. ISSN 1359-7345. PMCID PMC2790054.

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Since the elucidation of the structure of double helical DNA, the construction of small molecules that recognize and react at specific DNA sites has been an area of considerable interest. In particular, the study of transition metal complexes that bind DNA with specificity has been a burgeoning field. This growth has been due in large part to the useful properties of metal complexes, which possess a wide array of photophysical attributes and allow for the modular assembly of an ensemble of recognition elements. Here we review recent experiments in our laboratory aimed at the design and study of octahedral metal complexes that bind DNA non-covalently and target reactions to specific sites. Emphasis is placed both on the variety of methods employed to confer site-specificity and upon the many applications for these complexes. Particular attention is given to the family of complexes recently designed that target single base mismatches in duplex DNA through metallo-insertion.

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Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:This journal is © The Royal Society of Chemistry 2007. Received (in Cambridge, UK) 17th July 2007, Accepted 31st August 2007. First published on the web 20th September 2007. The authors would like to thank laboratory members past and present, along with many collaborators, for their efforts. We also thank the National Institutes of Health for their financial support (GM33309).
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Issue or Number:44
PubMed Central ID:PMC2790054
Record Number:CaltechAUTHORS:ZEGcc07
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9287
Deposited By: Archive Administrator
Deposited On:08 Dec 2007
Last Modified:02 Oct 2019 23:59

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