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The crystal structure of hydroxy‐L‐proline. II. Determination and description of the structure

Donohue, Jerry and Trueblood, Kenneth N. (1952) The crystal structure of hydroxy‐L‐proline. II. Determination and description of the structure. Acta Crystallographica, 5 (4). pp. 419-431. ISSN 0365-110X. doi:10.1107/S0365110X52001283.

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The determination of the crystal structure of hydroxy-L-proline, based on nearly complete data accessible with Cu Kα radiation, confirms the chemical assignment of the relative configurations about the two asymmetric carbon atoms, and leads to the following intramolecular bond distances: carboxyl group: C₁-O₁ = 1•25, C₁-O₂ = 1•27, Cr₁-C₂ = 1•52 Å; pyrrolidine ring: C₂-C₃ = 1•53, C₃-C₄ = 1•50, C₄-C₅ = 1•52, C₅-N = 1.48, N-C₂ = 1•50 Å; hydroxyl group : C₄-O₃ = 1•46 Å. The crystal is held together by a system of hydrogen bonds, with N...O₂ = 2•69, N...O'₂ = 3•17, O₃...O₁ = 2•80 Å. The molecule is in the Zwitterion form. These and various other structural features are discussed.

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Alternate Title:The crystal structure of hydroxy‐l‐proline. II. Determination and description of the structure
Additional Information:Received 20 November 1951. First published: July 1952. A preliminary report was presented at the Second Congress of the International Union of CrystaUography at Stockholm in June 1951, and a more detailed description was given at the XIIth International Congress of Pure and Applied Chemistry at New York, September 1951. Aided by a grant from the National Foundation for Infantile Paralysis and from the Lederle Laboratories.
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National Foundation for Infantile ParalysisUNSPECIFIED
Lederle LaboratoriesUNSPECIFIED
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Gates and Crellin Laboratories of Chemistry1627
Issue or Number:4
Record Number:CaltechAUTHORS:20190215-101956699
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92952
Deposited By: Katherine Johnson
Deposited On:15 Feb 2019 18:43
Last Modified:16 Nov 2021 16:54

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