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Dynamics of Co-Translational Membrane Integration

Miller, Thomas F. (2019) Dynamics of Co-Translational Membrane Integration. Biophysical Journal, 116 (3). 11a. ISSN 0006-3495. doi:10.1016/j.bpj.2018.11.096.

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Although proteins are synthesized only in specialized cellular locations, they are destined for delivery to all corners of the cell—and beyond. A key step in this delivery process is the efficient transport, or translocation, of the newly synthesized proteins across cell membranes, which involves a delicate balance between molecular processes. Recent studies offer high-resolution glimpses into the translocation process, but many fundamental aspects of its mechanism and regulation remain poorly understood. I will present our lab's efforts to computationally simulate the protein translocation process and to predict ways of controlling the in vivo targeting and delivery of proteins. This work employs methods that span across atomistic simulation, coarse-grained methods, machine learning techniques, and experimental collaborations.

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Miller, Thomas F.0000-0002-1882-5380
Additional Information:© 2019 Biophysical Society. Available online 15 February 2019.
Issue or Number:3
Record Number:CaltechAUTHORS:20190219-103922051
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Official Citation:Thomas F. Miller, Dynamics of Co-Translational Membrane Integration, Biophysical Journal, Volume 116, Issue 3, Supplement 1, 2019, Page 11a, ISSN 0006-3495, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:92970
Deposited By: Tony Diaz
Deposited On:19 Feb 2019 18:57
Last Modified:16 Nov 2021 16:54

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