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Host controlled variation in bacterial viruses

Bertani, G. and Weigle, J. J. (1953) Host controlled variation in bacterial viruses. Journal of Bacteriology, 65 (2). pp. 113-121. ISSN 0021-9193. PMCID PMC169650.

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Passage through new hosts or new tissues is a widely used method for altering the properties of viruses. In some instances selection of spontaneous mutants has been demonstrated to be the mechanism causing the variation (Luria, 1945). Nonhereditary mechanisms sometimes have been postulated, but since no such case has been analyzed sufficiently, it is often assumed that selection of mutants is the only possible mechanism. A detailed analysis of two cases of variation in two different bacterial viruses is reported in this paper. In both these cases we are dealing with nonheritable alterations stemming directly from passage through a new host and not with mutations. A somewhat similar case of host controlled variation involving other bacterial viruses has been reported recently by Luria and Human (1952).

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Additional Information:© 1953 Society of American Bacteriologists. Received for publication June 17, 1952. This work was supported by grants from the American Cancer Society, as recommended by the Committee on Growth of the National Research Council, and from The National Foundation for Infantile Paralysis. The authors are greatly indebted to Miss Shirley J. Nice for assistance; to Dr. Margaret Lieb for contributing information on phage desorption; to Dr. R. K. Appleyard for contributing data on the distribution of the "exceptional" plaques formed by λC on S; and finally to Drs. Max Delbrück and S. E. Luria for discussing the manuscript. After this manuscript had been completed, Dr. E. S. Anderson of the Central Enteric Reference Laboratory, Public Health Laboratory Service (Medical Research Council), London, informed us that some unpublished experiments carried out by himself and Dr. A. Felix in 1947 show that at least some of the variations observed with Vi-phage II of Craigie and Yen follow the patterns described in this paper, and cannot be explained on the basis of a selection of host-range mutants.
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American Cancer SocietyUNSPECIFIED
National Foundation for Infantile ParalysisUNSPECIFIED
Issue or Number:2
PubMed Central ID:PMC169650
Record Number:CaltechAUTHORS:20190226-093719469
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Official Citation:HOST CONTROLLED VARIATION IN BACTERIAL VIRUSES G. Bertani, J. J. Weigle Journal of Bacteriology Feb 1953, 65 (2) 113-121
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93253
Deposited By: George Porter
Deposited On:26 Feb 2019 18:06
Last Modified:03 Oct 2019 20:52

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