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Compensatory ingestion upon dietary restriction in Drosophila melanogaster

Carvalho, Gil B. and Kapahi, Pankaj and Benzer, Seymour (2005) Compensatory ingestion upon dietary restriction in Drosophila melanogaster. Nature Methods, 2 (11). pp. 813-815. ISSN 1548-7091. PMCID PMC2745347. doi:10.1038/nmeth798. https://resolver.caltech.edu/CaltechAUTHORS:20190226-160801941

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Abstract

Dietary restriction extends the lifespan of numerous, evolutionarily diverse species. In D. melanogaster, a prominent model for research on the interaction between nutrition and longevity, dietary restriction is typically based on medium dilution, with possible compensatory ingestion commonly being neglected. Possible problems with this approach are revealed by using a method for direct monitoring of D. melanogaster feeding behavior. This demonstrates that dietary restriction elicits robust compensatory changes in food consumption. As a result, the effect of medium dilution is overestimated and, in certain cases, even fully compensated for. Our results strongly indicate that feeding behavior and nutritional composition act concertedly to determine fly lifespan. Feeding behavior thus emerges as a central element in D. melanogaster aging.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/nmeth798DOIArticle
https://rdcu.be/boAYJPublisherFree ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745347PubMed CentralArticle
Additional Information:© 2005 Nature Publishing Group. Published 21 October 2005. Supported by a Lawrence L. and Audrey W. Ferguson Fellowship from the Caltech Division of Biology to G.B.C., a grant from the American Federation for Aging Research and a postdoctoral fellowship from the John Douglas French Foundation for Alzheimer's Research to P.K., and grants to S.B. from the US National Institutes of Health (AG16630, AG24366 and DK070154), the National Science Foundation (MCB-0418479) and the Ellison foundation.
Funders:
Funding AgencyGrant Number
Caltech Division of BiologyUNSPECIFIED
American Federation for Aging ResearchUNSPECIFIED
John Douglas French Alzheimer’s FoundationUNSPECIFIED
NIHAG16630
NIHAG24366
NIHDK070154
NSFMCB-0418479
Ellison Medical FoundationUNSPECIFIED
Issue or Number:11
PubMed Central ID:PMC2745347
DOI:10.1038/nmeth798
Record Number:CaltechAUTHORS:20190226-160801941
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190226-160801941
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93280
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Feb 2019 00:15
Last Modified:16 Nov 2021 16:56

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