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High-speed photoacoustic microscopy of mouse cortical microhemodynamics

Lin, Li and Yao, Junjie and Zhang, Ruiying and Chen, Chun-Cheng and Huang, Chih-Hsien and Li, Yang and Wang, Lidai and Chapman, William and Zou, Jun and Wang, Lihong V. (2017) High-speed photoacoustic microscopy of mouse cortical microhemodynamics. Journal of Biophotonics, 10 (6-7). pp. 792-798. ISSN 1864-063X. PMCID PMC5576888. doi:10.1002/jbio.201600236.

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We applied high‐speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer‐level optical resolution and a millisecond‐level cross‐sectional imaging speed over a millimeter‐level field of view. We monitored blood flow redistribution in mini‐stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high‐speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Lin, Li0000-0002-0517-8436
Zhang, Ruiying0000-0002-0092-0814
Li, Yang0000-0002-4939-8174
Zou, Jun0000-0002-9543-6135
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. Received 9 September 2016, revised 28 November 2016, accepted 7 December 2016, Published online 24 December 2016. The authors appreciate Prof. James Ballard's close reading of the manuscript. We also thank Peng Hu for image processing. This work was sponsored by NIH grants R01 CA186567 (NIH Director's Transformative Research Award), and R01 CA159959 (for L. V. Wang), and NSF grant IDBR‐1255921 (for J. Zou). L. V. Wang has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHR01 CA186567
NIHR01 CA159959
Subject Keywords:photoacoustic microscopy; MEMS scanning mirror; cortical hemodynamics; blood flow redistribution; microhemorrhage; cerebral autoregulation
Issue or Number:6-7
PubMed Central ID:PMC5576888
Record Number:CaltechAUTHORS:20190227-073226908
Persistent URL:
Official Citation:Lin, L. , Yao, J. , Zhang, R. , Chen, C. , Huang, C. , Li, Y. , Wang, L. , Chapman, W. , Zou, J. and Wang, L. V. (2017), High‐speed photoacoustic microscopy of mouse cortical microhemodynamics. J. Biophoton., 10: 792-798. doi:10.1002/jbio.201600236
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93282
Deposited By: Tony Diaz
Deposited On:27 Feb 2019 17:27
Last Modified:16 Nov 2021 16:56

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