High-speed photoacoustic microscopy of mouse cortical microhemodynamics

Lin, Li and Yao, Junjie and Zhang, Ruiying and Chen, Chun-Cheng and Huang, Chih-Hsien and Li, Yang and Wang, Lidai and Chapman, William and Zou, Jun and Wang, Lihong V. (2017) High-speed photoacoustic microscopy of mouse cortical microhemodynamics. Journal of Biophotonics, 10 (6-7). pp. 792-798. ISSN 1864-063X. PMCID PMC5576888. doi:10.1002/jbio.201600236. https://resolver.caltech.edu/CaltechAUTHORS:20190227-073226908

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Abstract

We applied high‐speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer‐level optical resolution and a millisecond‐level cross‐sectional imaging speed over a millimeter‐level field of view. We monitored blood flow redistribution in mini‐stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high‐speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.

Item Type:

Article

Related URLs:

URL	URL Type	Description
https://doi.org/10.1002/jbio.201600236	DOI	Article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576888	PubMed Central	Article

ORCID:

Author	ORCID
Lin, Li	0000-0002-0517-8436
Zhang, Ruiying	0000-0002-0092-0814
Li, Yang	0000-0002-4939-8174
Zou, Jun	0000-0002-9543-6135
Wang, Lihong V.	0000-0001-9783-4383

Additional Information:

© 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. Received 9 September 2016, revised 28 November 2016, accepted 7 December 2016, Published online 24 December 2016. The authors appreciate Prof. James Ballard's close reading of the manuscript. We also thank Peng Hu for image processing. This work was sponsored by NIH grants R01 CA186567 (NIH Director's Transformative Research Award), and R01 CA159959 (for L. V. Wang), and NSF grant IDBR‐1255921 (for J. Zou). L. V. Wang has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work.

Funders:

Funding Agency	Grant Number
NIH	R01 CA186567
NIH	R01 CA159959
NSF	IDBR-1255921

Subject Keywords:

photoacoustic microscopy; MEMS scanning mirror; cortical hemodynamics; blood flow redistribution; microhemorrhage; cerebral autoregulation

Issue or Number:

6-7

PubMed Central ID:

PMC5576888

DOI:

10.1002/jbio.201600236

Record Number:

CaltechAUTHORS:20190227-073226908

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20190227-073226908

Official Citation:

Lin, L. , Yao, J. , Zhang, R. , Chen, C. , Huang, C. , Li, Y. , Wang, L. , Chapman, W. , Zou, J. and Wang, L. V. (2017), High‐speed photoacoustic microscopy of mouse cortical microhemodynamics. J. Biophoton., 10: 792-798. doi:10.1002/jbio.201600236

Usage Policy:

No commercial reproduction, distribution, display or performance rights in this work are provided.

ID Code:

93282

Collection:

CaltechAUTHORS

Deposited By:

Tony Diaz

Deposited On:

27 Feb 2019 17:27

Last Modified:

16 Nov 2021 16:56

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