Lin, Li and Yao, Junjie and Zhang, Ruiying and Chen, Chun-Cheng and Huang, Chih-Hsien and Li, Yang and Wang, Lidai and Chapman, William and Zou, Jun and Wang, Lihong V. (2017) High-speed photoacoustic microscopy of mouse cortical microhemodynamics. Journal of Biophotonics, 10 (6-7). pp. 792-798. ISSN 1864-063X. PMCID PMC5576888. https://resolver.caltech.edu/CaltechAUTHORS:20190227-073226908
![[img]](https://authors.library.caltech.edu/style/images/fileicons/application_pdf.png) |
PDF
- Accepted Version
See Usage Policy. 982Kb |
![[img]](https://authors.library.caltech.edu/style/images/fileicons/video.png) |
Video (WMV) (Video 1)
- Supplemental Material
See Usage Policy. 4Mb |
|
Video (WMV) (Video 2)
- Supplemental Material
See Usage Policy. 3691Kb |
|
Video (WMV) (Video 3)
- Supplemental Material
See Usage Policy. 4Mb |
|
Video (WMV) (Video 4)
- Supplemental Material
See Usage Policy. 1672Kb |
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20190227-073226908
Abstract
We applied high‐speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer‐level optical resolution and a millisecond‐level cross‐sectional imaging speed over a millimeter‐level field of view. We monitored blood flow redistribution in mini‐stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high‐speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.
| Item Type: | Article | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Related URLs: |
| |||||||||
| ORCID: |
| |||||||||
| Additional Information: | © 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. Received 9 September 2016, revised 28 November 2016, accepted 7 December 2016, Published online 24 December 2016. The authors appreciate Prof. James Ballard's close reading of the manuscript. We also thank Peng Hu for image processing. This work was sponsored by NIH grants R01 CA186567 (NIH Director's Transformative Research Award), and R01 CA159959 (for L. V. Wang), and NSF grant IDBR‐1255921 (for J. Zou). L. V. Wang has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work. | |||||||||
| Funders: |
| |||||||||
| Subject Keywords: | photoacoustic microscopy; MEMS scanning mirror; cortical hemodynamics; blood flow redistribution; microhemorrhage; cerebral autoregulation | |||||||||
| Issue or Number: | 6-7 | |||||||||
| PubMed Central ID: | PMC5576888 | |||||||||
| Record Number: | CaltechAUTHORS:20190227-073226908 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20190227-073226908 | |||||||||
| Official Citation: | Lin, L. , Yao, J. , Zhang, R. , Chen, C. , Huang, C. , Li, Y. , Wang, L. , Chapman, W. , Zou, J. and Wang, L. V. (2017), High‐speed photoacoustic microscopy of mouse cortical microhemodynamics. J. Biophoton., 10: 792-798. doi:10.1002/jbio.201600236 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 93282 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 27 Feb 2019 17:27 | |||||||||
| Last Modified: | 03 Oct 2019 20:52 |
Repository Staff Only: item control page
