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Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

Yuan, Hsiangkuo and Wilson, Christy M. and Xia, Jun and Doyle, Sarah L. and Li, Shuqin and Fales, Andrew M. and Liu, Yang and Ozaki, Ema and Mulfaul, Kelly and Hanna, Gabi and Palmer, Gregory M. and Wang, Lihong V. and Grant, Gerald A. and Vo-Dinh, Tuan (2014) Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor. Nanoscale, 6 (8). pp. 4078-4082. ISSN 2040-3364. PMCID PMC4343032.

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Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Liu, Yang0000-0002-8155-9134
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 The Royal Society of Chemistry. The article was received on 21 Dec 2013, accepted on 26 Feb 2014 and first published on 04 Mar 2014. This work was supported in part from the National Institutes of Health (Grant R01 EB006201, T32 EB001040, 5K08-NS075144-03, DP1 EB016986, R01 EB016963), the Department of Defense (DOD Award W81XWH-09-1-0064), the Defense Advanced Research Projects Agency (HR0011-13-2-0003), the Duke Exploratory Research Funds, and National Children's Research Centre (NCRC) Funds. The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. The authors would like to thank Dr Darell Bigner and the Duke Preston Robert Tisch Brain Tumor Center for their support of the human brain tumor xenografts used in the orthotopic mouse models, as well as Dr Sam Johnson and the Duke Light Microscopy Core Facility for their expertise in multiphoton microscopy.
Funding AgencyGrant Number
NIHR01 EB006201
NIH Predoctoral FellowshipT32 EB001040
NIHDP1 EB016986
NIHR01 EB016963
Department of DefenseW81XWH-09-1-0064
Defense Advanced Research Projects Agency (DARPA)HR0011-13-2-0003
Duke UniversityUNSPECIFIED
National Children's Research CentreUNSPECIFIED
Issue or Number:8
PubMed Central ID:PMC4343032
Record Number:CaltechAUTHORS:20190227-104319278
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93298
Deposited By: Tony Diaz
Deposited On:27 Feb 2019 18:58
Last Modified:09 Mar 2020 13:19

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