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Graphene-based contrast agents for photoacoustic and thermoacoustic tomography

Lalwani, Gaurav and Cai, Xin and Nie, Liming and Wang, Lihong V. and Sitharaman, Balaji (2013) Graphene-based contrast agents for photoacoustic and thermoacoustic tomography. Photoacoustics, 1 (3-4). pp. 62-67. ISSN 2213-5979. PMCID PMC3904379. doi:10.1016/j.pacs.2013.10.001. https://resolver.caltech.edu/CaltechAUTHORS:20190227-110952823

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Abstract

In this work, graphene nanoribbons and nanoplatelets were investigated as contrast agents for photoacoustic and thermoacoustic tomography (PAT and TAT). We show that oxidized single- and multi-walled graphene oxide nanoribbons (O-SWGNRs, O-MWGNRs) exhibit approximately 5–10 fold signal enhancement for PAT in comparison to blood at the wavelength of 755 nm, and approximately 10–28% signal enhancement for TAT in comparison to deionized (DI) water at 3 GHz. Oxidized graphite microparticles (O-GMPs) and exfoliated graphene oxide nanoplatelets (O-GNPs) show no significant signal enhancement for PAT, and approximately 12–29% signal enhancement for TAT. These results indicate that O-GNRs show promise as multi-modal PAT and TAT contrast agents, and that O-GNPs are suitable contrast agents for TAT.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.pacs.2013.10.001DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904379PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 The Authors. Published by Elsevier GmbH. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. Received 14 July 2013, Revised 18 September 2013, Accepted 8 October 2013, Available online 22 October 2013. We are grateful to Sandra Matteucci for proof reading of the manuscript. Our work was sponsored by NIH Director's New Innovator Award 1DP2OD007394-01 (to S.B.), Wallace H. Coulter Foundation (S.B.), and NIH grants R01 EB008085, R01 CA140220, R01 CA157277, R01 CA159959, U54 CA136398, and DP1 EB016986 – NIH Director's Pioneer Award (to L.V.W.). L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. The authors declare no conflict of interest.
Funders:
Funding AgencyGrant Number
NIH1DP2OD007394-01
Wallace H. Coulter FoundationUNSPECIFIED
NIHR01 EB008085
NIHR01 CA140220
NIHR01 CA157277
NIHR01 CA159959
NIHU54 CA136398
NIHDP1 EB016986
Subject Keywords:Graphene; Photoacoustic tomography; Thermoacoustic tomography; Contrast agents; Microwave imaging
Issue or Number:3-4
PubMed Central ID:PMC3904379
DOI:10.1016/j.pacs.2013.10.001
Record Number:CaltechAUTHORS:20190227-110952823
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190227-110952823
Official Citation:Gaurav Lalwani, Xin Cai, Liming Nie, Lihong V. Wang, Balaji Sitharaman, Graphene-based contrast agents for photoacoustic and thermoacoustic tomography, Photoacoustics, Volume 1, Issues 3–4, 2013, Pages 62-67, ISSN 2213-5979, https://doi.org/10.1016/j.pacs.2013.10.001. (http://www.sciencedirect.com/science/article/pii/S2213597913000293)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93300
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Feb 2019 19:18
Last Modified:16 Nov 2021 16:56

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