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Graphene-based contrast agents for photoacoustic and thermoacoustic tomography

Lalwani, Gaurav and Cai, Xin and Nie, Liming and Wang, Lihong V. and Sitharaman, Balaji (2013) Graphene-based contrast agents for photoacoustic and thermoacoustic tomography. Photoacoustics, 1 (3-4). pp. 62-67. ISSN 2213-5979. PMCID PMC3904379. doi:10.1016/j.pacs.2013.10.001.

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In this work, graphene nanoribbons and nanoplatelets were investigated as contrast agents for photoacoustic and thermoacoustic tomography (PAT and TAT). We show that oxidized single- and multi-walled graphene oxide nanoribbons (O-SWGNRs, O-MWGNRs) exhibit approximately 5–10 fold signal enhancement for PAT in comparison to blood at the wavelength of 755 nm, and approximately 10–28% signal enhancement for TAT in comparison to deionized (DI) water at 3 GHz. Oxidized graphite microparticles (O-GMPs) and exfoliated graphene oxide nanoplatelets (O-GNPs) show no significant signal enhancement for PAT, and approximately 12–29% signal enhancement for TAT. These results indicate that O-GNRs show promise as multi-modal PAT and TAT contrast agents, and that O-GNPs are suitable contrast agents for TAT.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 The Authors. Published by Elsevier GmbH. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. Received 14 July 2013, Revised 18 September 2013, Accepted 8 October 2013, Available online 22 October 2013. We are grateful to Sandra Matteucci for proof reading of the manuscript. Our work was sponsored by NIH Director's New Innovator Award 1DP2OD007394-01 (to S.B.), Wallace H. Coulter Foundation (S.B.), and NIH grants R01 EB008085, R01 CA140220, R01 CA157277, R01 CA159959, U54 CA136398, and DP1 EB016986 – NIH Director's Pioneer Award (to L.V.W.). L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. The authors declare no conflict of interest.
Funding AgencyGrant Number
Wallace H. Coulter FoundationUNSPECIFIED
NIHR01 EB008085
NIHR01 CA140220
NIHR01 CA157277
NIHR01 CA159959
NIHU54 CA136398
NIHDP1 EB016986
Subject Keywords:Graphene; Photoacoustic tomography; Thermoacoustic tomography; Contrast agents; Microwave imaging
Issue or Number:3-4
PubMed Central ID:PMC3904379
Record Number:CaltechAUTHORS:20190227-110952823
Persistent URL:
Official Citation:Gaurav Lalwani, Xin Cai, Liming Nie, Lihong V. Wang, Balaji Sitharaman, Graphene-based contrast agents for photoacoustic and thermoacoustic tomography, Photoacoustics, Volume 1, Issues 3–4, 2013, Pages 62-67, ISSN 2213-5979, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93300
Deposited By: Tony Diaz
Deposited On:27 Feb 2019 19:18
Last Modified:16 Nov 2021 16:56

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