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Transvection at the eyes absent gene of Drosophila

Leiserson, William M. and Bonini, Nancy M. and Benzer, Seymour (1994) Transvection at the eyes absent gene of Drosophila. Genetics, 138 (4). pp. 1171-1179. ISSN 0016-6731. PMCID PMC1206256.

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The Drosophila eyes absent (eya) gene is required for survival and differentiation of eye progenitor cells. Loss of gene function in the eye results in reduction or absence of the adult compound eye. Certain combinations of eya alleles undergo partial complementation, with dramatic restoration of eye size. This interaction is sensitive to the relative positions of the two alleles in the genome; rearrangements predicted to disrupt pairing of chromosomal homologs in the eya region disrupt complementation. Ten X-ray-induced rearrangements that suppress the interaction obey the same general rules as those that disrupt transvection at the bithorax complex and the decapentaplegic gene. Moreover, like transvection in those cases, the interaction at eya depends on the presence of normal zeste function. The discovery of transvection at eya suggests that transvection interactions of this type may be more prevalent than generally thought.

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Additional Information:© 1994 by the Genetics Society of America. Manuscript received June 6, 1994; Accepted for publication August 25, 1994. The authors thank EDWARD B. LEWIS for many helpful discussions and comments on the manuscript. We express our gratitude for the excellent technical assistance of EVELINE EICHENBERGER, CHRISTINE PHAM, ROSALIND YOUNG and LYNETTE DOWLING. In addition we are grateful to SUSAN CELNIKER, KONRAD ZINSMAIER, ELIZABETH HARKINS and MARC HALFON for critical reviews of the manuscript. This research was supported by postdoctoral fellowships (to N .M.B) from the American Cancer Society, California Division Fellowship S-49-91 and American Cancer Society, National Office, Postdoctoral Fellowship PF-4000 and grants (to S.B.) from the National Science Foundation (BCS 8908154), the National Eye Institute of the National Institutes of Health (EY09278), and the James G. Boswell Foundation.
Funding AgencyGrant Number
American Cancer SocietyS-49-91
American Cancer SocietyPF-4000
James G. Boswell FoundationUNSPECIFIED
Issue or Number:4
PubMed Central ID:PMC1206256
Record Number:CaltechAUTHORS:20190227-112246122
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Official Citation:Transvection at the eyes absent gene of Drosophila. W M Leiserson, N M Bonini and S Benzer. GENETICS December 1, 1994 vol. 138 no. 4 1171-1179
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93302
Deposited By: Tony Diaz
Deposited On:27 Feb 2019 19:37
Last Modified:03 Oct 2019 20:52

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