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Neuronal development in the drosophila retina: Monoclonal antibodies as molecular probes

Zipursky, S. L. and Venkatesh, Tadmiri R. and Teplow, David B. and Benzer, Seymour (1984) Neuronal development in the drosophila retina: Monoclonal antibodies as molecular probes. Cell, 36 (1). pp. 15-26. ISSN 0092-8674. doi:10.1016/0092-8674(84)90069-2.

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The compound eye of D. melanogaster is a reiterative pattern of facets, each containing eight photoreceptor cells in a precise arrangement. This pattern is established in the eye imaginal disc during the third larval instar. A wave of morphogenesis sweeps from posterior to anterior across the disc, leaving in its wake organized clusters of photoreceptor cells. We have used monoclonal antibodies to highlight pattern elements that are not readily observable by other techniques. Monoclonal antibodies can be used to identify the molecules associated with particular patterns, providing links between observable structures and the genes. As an example, we present the purification and N-terminal sequence of a glycoprotein antigen specific to photoreceptor cells and their axons.

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Additional Information:© 1984 MIT. Received October 18, 1983. We gratefully acknowledge the expert technical assistance of Marika Szalay and Devra Ellert We thank Carol Miller and Mark Tanouye for helpful discussions. The protein sequenator was generously made available by Dr. William Dreyer. This work was supported by National Science Foundation grant PCM 79-11771 (S. B.). fellowships from the Helen Hay Whitney Foundation (S. L. 2.) and the Gosney Foundation (T. R. V.), and National Institutes of Health grant 2-T32-GM07401-06 (D. B. T.). The costs of publication of this article were defrayed rn part by the payment of page charges. Thus article must therefore be hereby marked “advertisement” In accordance with 18 USC. Section 1734 solely to indicate thus fact.
Funding AgencyGrant Number
NSFPCM 79-11771
Helen Hay Whitney FoundationUNSPECIFIED
Gosney FoundationUNSPECIFIED
NIH Predoctoral Fellowship2-T32-GM07401-06
Issue or Number:1
Record Number:CaltechAUTHORS:20190227-140300257
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Official Citation:S.L. Zipursky, Tadmiri R. Venkatesh, David B. Teplow, Seymour Benzer, Neuronal development in the drosophila retina: Monoclonal antibodies as molecular probes, Cell, Volume 36, Issue 1, 1984, Pages 15-26, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93307
Deposited By: George Porter
Deposited On:27 Feb 2019 22:13
Last Modified:16 Nov 2021 16:56

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