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Monoclonal antibody probes discriminate early and late mutant defects in development of the Drosophila retina

Renfranz, Patricia J. and Benzer, Seymour (1989) Monoclonal antibody probes discriminate early and late mutant defects in development of the Drosophila retina. Developmental Biology, 136 (2). pp. 411-429. ISSN 0012-1606. http://resolver.caltech.edu/CaltechAUTHORS:20190227-142540938

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Abstract

Many mutations in Drosophila melanogaster affect the morphology of the adult compound eye. However, the times at which the phenotypes first become manifest in development are, in most cases, unknown; they can occur at any of a series of stages. Among mutants in which the adult eyes appear externally similar, the developmental stage of onset of each defect may be quite different. Pattern formation in the compound eye begins during the late third larval instar in the eye imaginal disc, when a wave of morphogenesis crosses the disc from posterior to anterior. As this wave crosses the disc, there appears in its wake an array of photoreceptor neuron clusters and accessory cells that will comprise the adult ommatidia. Eye discs from 20 abnormal-eye mutants were analyzed using monoclonal antibodies that highlight various aspects of the developing array, to observe the stage at which each anomaly becomes evident. Some mutations apparently affect precursor cells, others the setting up of the pattern, others maintenance of the pattern, and still others later morphogenetic events.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0012-1606(89)90267-4DOIArticle
Additional Information:© 1989 Academic Press, Inc. Accepted 8 August 1989. This work was supported by a grant to S.B. (DCB-8409366) from the National Science Foundation. We thank E. Eichenberger and R. Young for expert technical assistance; W. Leiserson for help with the scanning electron microscopy; R. Hackett, W. Leiserson, and N. Bonini for allowing us to include some of their eya data; and our colleagues for comments on the manuscript. This work was supported by a grant to S.B. (DCB-8409366) from the National Science Foundation. P.J.R. was supported in part by a National Research Service Award (1 T32GM07616) from the National Institute of General Medical Sciences and by the Lawrence A. Hanson Foundation. It is based in part on the thesis by Patricia Renfranz (1989) in satisfaction of the requirements for the Ph.D. degree.
Funders:
Funding AgencyGrant Number
NSFDCB-8409366
NIH Predoctoral FellowshipT32GM07616
Lawrence A. Hanson FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20190227-142540938
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190227-142540938
Official Citation:Monoclonal antibody probes discriminate early and late mutant defects in development of the Drosophila retina, Developmental Biology, Volume 136, Issue 2, 1989, Pages 411-429, ISSN 0012-1606, https://doi.org/10.1016/0012-1606(89)90267-4. (http://www.sciencedirect.com/science/article/pii/0012160689902674)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93311
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Feb 2019 22:32
Last Modified:27 Feb 2019 22:32

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