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Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster

Seroude, Laurent and Brummel, Ted and Kapahi, Pankaj and Benzer, Seymour (2002) Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster. Aging Cell, 1 (1). pp. 47-56. ISSN 1474-9718. doi:10.1046/j.1474-9728.2002.00007.x.

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The relationship between gene expression and the regulation of longevity is poorly understood. Previous studies focusing on microarray or tissue‐specific changes in gene expression as a function of age have provided evidence that gene expression is a dynamic process which is regulated, even late in an organism's lifespan. Using the enhancer‐trap technique, a systematic analysis of the spatio‐temporal regulation of gene expression in tissues of adult Drosophila is presented. As many as 80% of enhancer traps analysed displayed (some form of) transcriptional change with age. In some cases the rate of change in expression was found to correlate with changes in longevity under various conditions, suggesting that they may be indicators of ‘physiological age’ and therefore valuable markers for dissecting the aging process. Molecular analysis of enhancer traps that showed increased activity with age was performed to identify candidate genes that may be important in the regulation of longevity; we identified changes in reporters associated with immunity, microtubule organization and muscle function.

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Additional Information:© 2002 Anatomical Society of Great Britain and Ireland. Issue Online: 15 September 2002; Version of Record online: 15 September 2002; Editorial history: Accepted for publication 11 June 2002. We thank Rosalind Young, Teddy Kassa, Lily Lan, Amparo Gomez and Stephanie Cornelisson for the excellent technical assistance and members of our research group for helpful discussions. Support by a postdoctoral fellowship from Caltech (T.B.), the Wellcome Trust (P.K.) and by grants (S.B.) from NSF (MCB 9907939), NIH (AG 16634) and the Ellison foundation.
Funding AgencyGrant Number
NIHAG 16634
Ellison Medical FoundationUNSPECIFIED
Subject Keywords:enhancer‐trap; immunity; lifespan; microtubule organization; muscle function
Issue or Number:1
Record Number:CaltechAUTHORS:20190227-144757284
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Official Citation:Seroude, L. , Brummel, T. , Kapahi, P. and Benzer, S. (2002), Spatio‐temporal analysis of gene expression during aging in Drosophila melanogaster. Aging Cell, 1: 47-56. doi:10.1046/j.1474-9728.2002.00007.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93313
Deposited By: Tony Diaz
Deposited On:27 Feb 2019 22:59
Last Modified:16 Nov 2021 16:56

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