A Caltech Library Service

The recently reported NIβ domain is already known as the Calx-β motif

Schwarz, Erich and Benzer, Seymour (1999) The recently reported NIβ domain is already known as the Calx-β motif. Trends in Biochemical Sciences, 24 (7). p. 260. ISSN 0968-0004. doi:10.1016/s0968-0004(99)01422-x.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


May and Ponting recently described homologies between integrin-α-subunit and -β-subunit domains and cyanobacterial proteins. However, their analysis of integrin-β homologies reports findings that we published 16 months earlier. Before discussing this, we wish to make clear that this recapitulation of our work was not the sole focus of their article: their demonstration that integrin-α and -β domains coexist in a single bacterial polypeptide remains novel and interesting. We discovered a motif, the Calx-β motif, that is present as a tandem repeat in the cytoplasmic domains of mammalian 3Na+/1Ca2+ exchangers (NCX1, etc.) and of their invertebrate orthologs (CALX, C10G8.5, etc.). The Calx-β motif is also present in the cytoplasmic tail of mammalian integrin β4 and in three functionally uncharacterized Synechocystis sp. PCC6803 proteins (slr0408, slr1028 and slr1403). The Calx-β motif overlaps domains used by NCX1 for calcium binding and regulation. Our analysis of the Calx-β motif, using the PHD neural network, indicated that it contains a series of β-strands and turns, which is consistent with the Calx-β motif forming a self-contained β-sheet.

Item Type:Article
Related URLs:
URLURL TypeDescription
Schwarz, Erich0000-0003-3151-4381
Additional Information:© 1999 Elsevier. Available online 9 July 1999.
Subject Keywords:Integrin; NIβ domain; Calx-β motif; Na+/Ca+ exchangers
Issue or Number:7
Record Number:CaltechAUTHORS:20190228-115827514
Persistent URL:
Official Citation:Erich Schwarz, Seymour Benzer, The recently reported NIβ domain is already known as the Calx-β motif, Trends in Biochemical Sciences, Volume 24, Issue 7, 1999, Page 260, ISSN 0968-0004, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93346
Deposited By: George Porter
Deposited On:28 Feb 2019 21:30
Last Modified:16 Nov 2021 16:57

Repository Staff Only: item control page